Dissertation/ Thesis
Παρέμβαση για τη βελτίωση της αντιμικροβιακής προφύλαξης σε επεμβάσεις αορτοστεφανιαίας παράκαμψης και αντικατάστασης καρδιακών βαλβίδων ; Intervention to improve antimicrobial prophylaxis in coronary artery bypass and heart valve replacement surgery
| العنوان: | Παρέμβαση για τη βελτίωση της αντιμικροβιακής προφύλαξης σε επεμβάσεις αορτοστεφανιαίας παράκαμψης και αντικατάστασης καρδιακών βαλβίδων ; Intervention to improve antimicrobial prophylaxis in coronary artery bypass and heart valve replacement surgery |
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| المؤلفون: | Kostourou, Sofia, Κωστούρου, Σοφία |
| بيانات النشر: | National and Kapodistrian University of Athens Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ) |
| سنة النشر: | 2023 |
| المجموعة: | National Archive of PhD Theses (National Documentation Centre Greece) |
| مصطلحات موضوعية: | Χειρουργική προφύλαξη, Επεμβάσεις αορτοστεφανιαίας παράκαμψης, Επεμβάσεις αντικατάστασης καρδιακών βαλβίδων, Συμμόρφωση, Ορθολογική χορήγηση αντιμικροβιακών, Surgical antimicrobial prophylaxis, Coronary artery bypass grafting, Heart valve replacement surgery, Compliance, Antibiotic stewardship, Επιστήμες Υγείας, Ιατρική και Επιστήμες Υγείας, Νοσηλευτική, Health Sciences, Medical and Health Sciences, Nursing |
| الوصف: | Introduction: Coronary artery by-pass grafting and Cardiac valve replacement surgery result in significant benefits for patients, in terms of survival and improvement of quality of life. Surgical-site infections, particularly the deep ones such as mediastinitis are challenging to treat and are accompanied with important increase of morbidity, mortality and cost of healthcare delivery. This is why although surgical wound of cardiothoracic surgeries characterized as ‘clean’ surgical antimicrobial prophylaxis or perioperative antibiotic prophylaxis (PAP) is always recommended. Perioperative antibiotic prophylaxis is a part of recommendations for prevention of surgical-site infections, in order to attain the optimal outcomes in patients undergoing surgery. The adherence to recommendations of correct use of PAP is essential to be effective. The correct use is assessed according to specific criteria, the right selection of drug in the right dose, the right time to initiate the administration, the perseverance of therapeutic drug levels with correct redosing when is needed and the right duration. Except the increase of surgical-site infections, noncompliance with recommendations increases the Clostridium difficile infections and other negative results such as toxicity and allergic reactions. Moreover, noncompliance favors the evolution of antimicrobial resistance, especially the prolonged duration. For the all the above reasons, compliance with recommendations consists a necessary part to all antibiotic stewardship programs. The effort to improve compliance in correct use of PAP is critical, particularly in Greece due to the fact that the rate of the antimicrobial consumption and the prevalence of multi-drug resistant organisms are among the highest in Europe. Although guidelines for PAP have been issued, limited data is available regarding the degree of compliance with these guidelines in cardiothoracic patients in Greece. Aim: The main aim of this study was the assessment of current practices of surgical prophylaxis ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | Greek, Modern (1453-) |
| Relation: | http://hdl.handle.net/10442/hedi/55489 |
| DOI: | 10.12681/eadd/55489 |
| الاتاحة: | http://hdl.handle.net/10442/hedi/55489 https://doi.org/10.12681/eadd/55489 |
| رقم الانضمام: | edsbas.31E45F74 |
| قاعدة البيانات: | BASE |
| DOI: | 10.12681/eadd/55489 |
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