Academic Journal
RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs
| العنوان: | RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs |
|---|---|
| المؤلفون: | Franco, Aldo, Kompella, Shiva N., Akondi, Kalyana B., Melaun, Christian, Daly, Norelle L., Luetje, Charles W., Alewood, Paul F., Craik, David J., Adams. David J., Mari, Frank |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2012 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Conus regius, α-Conotoxin, Nicotinic acetylcholine receptor, NMR structure, Nicotine addiction, 1303 Biochemistry, 3004 Pharmacology |
| الوصف: | Neuronal nicotinic acetylcholine receptors (nAChRs) play pivotal roles in the central and peripheral nervous systems. They are implicated in disease states such as Parkinson's disease and schizophrenia, as well as addictive processes for nicotine and other drugs of abuse. Modulation of specific nAChRs is essential to understand their role in the CNS. alpha-Conotoxins, disulfide-constrained peptides isolated from the venom of cone snails, potently inhibit nAChRs. Their selectivity varies markedly depending upon the specific nAChR subtype/alpha-conotoxin pair under consideration. Thus, alpha-conotoxins are excellent probes to evaluate the functional roles of nAChRs subtypes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0006-2952 1873-2968 |
| Relation: | orcid:0000-0001-7454-6522; orcid:0000-0003-0007-6796; 1R15GM066004-01A1; R/LR-MB-28 |
| الاتاحة: | https://espace.library.uq.edu.au/view/UQ:263995 |
| رقم الانضمام: | edsbas.31A7A00C |
| قاعدة البيانات: | BASE |
| تدمد: | 00062952 18732968 |
|---|