Academic Journal
Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients
| العنوان: | Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients |
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| المؤلفون: | Tansley, SL, Betteridge, ZE, Simou, S, Jacques, TS, Pilkington, C, Wood, M, Warrier, K, Wedderburn, LR, McHugh, NJ, Juvenile Dermatomyositis Research Group |
| المصدر: | The Journal of Rheumatology , 44 (4) pp. 488-492. (2017) |
| سنة النشر: | 2017 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Pediatric Dermatomyositis/polymyositis, Pediatric Rheumatic Diseases, Autoantibodies, Prognosis |
| الوصف: | OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis. METHODS: There were 381 patients investigated for anti-HMGCR using ELISA. RESULTS: Anti-HMGCR autoantibodies were detected in 4 patients (1%). These children had no or minimal rash and significant muscle disease. Muscle biopsies were considered distinctive, with widespread variation in fiber size, necrotic fibers, and chronic inflammatory cell infiltrates; all had prolonged elevation of creatine kinase and all ultimately received biologic therapies. CONCLUSION: Anti-HMGCR in UK children with myositis are associated with severe disease that is poorly responsive to standard treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/1542828/1/Jacques_Anti-HMGCR%20Autoantibodies%20in%20Juvenile%20Idiopathic.pdf; https://discovery.ucl.ac.uk/id/eprint/1542828/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/1542828/1/Jacques_Anti-HMGCR%20Autoantibodies%20in%20Juvenile%20Idiopathic.pdf https://discovery.ucl.ac.uk/id/eprint/1542828/ |
| Rights: | open |
| رقم الانضمام: | edsbas.319E919E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |