Academic Journal
SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36
| العنوان: | SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36 |
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| المؤلفون: | Yang, Yunhan, Li, Yanping, Sears, Rosalie C., Sun, Xiao-Xin, Dai, Mu-Shui |
| المصدر: | Frontiers in RNA Research ; volume 2 ; ISSN 2813-7116 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2024 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Ribosome biogenesis is essential for cell growth, proliferation, and animal development. Its deregulation leads to various human disorders such as ribosomopathies and cancer. Thus, tight regulation of ribosome biogenesis is crucial for normal cell homeostasis. Emerging evidence suggests that posttranslational modifications such as ubiquitination and SUMOylation play a crucial role in regulating ribosome biogenesis. Our recent studies reveal that USP36, a nucleolar deubiquitinating enzyme (DUB), acts also as a SUMO ligase to regulate nucleolar protein group SUMOylation, thereby being essential for ribosome biogenesis. Here, we provide an overview of the current understanding of the SUMOylation regulation of ribosome biogenesis and discuss the role of USP36 in nucleolar SUMOylation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/frnar.2024.1389104 |
| DOI: | 10.3389/frnar.2024.1389104/full |
| الاتاحة: | http://dx.doi.org/10.3389/frnar.2024.1389104 https://www.frontiersin.org/articles/10.3389/frnar.2024.1389104/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.31964637 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/frnar.2024.1389104 |
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