التفاصيل البيبلوغرافية
| العنوان: |
Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells |
| المؤلفون: |
Hyeon-Yeol Cho, Jin-Ha Choi, Joungpyo Lim, Sang-Nam Lee, Jeong-Woo Choi |
| المصدر: |
Cancers; Volume 13; Issue 6; Pages: 1385 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
liquid biopsy, microfluidic platform, circulating tumor cells, circulating cancer stem cells, optical sensing, early diagnosis |
| الوصف: |
Detecting circulating tumor cells (CTCs) has been considered one of the best biomarkers in liquid biopsy for early diagnosis and prognosis monitoring in cancer. A major challenge of using CTCs is detecting extremely low-concentrated targets in the presence of high noise factors such as serum and hematopoietic cells. This review provides a selective overview of the recent progress in the design of microfluidic devices with optical sensing tools and their application in the detection and analysis of CTCs and their small malignant subset, circulating cancer stem cells (CCSCs). Moreover, discussion of novel strategies to analyze the differentiation of circulating cancer stem cells will contribute to an understanding of metastatic cancer, which can help clinicians to make a better assessment. We believe that the topic discussed in this review can provide brief guideline for the development of microfluidic-based optical biosensors in cancer prognosis monitoring and clinical applications. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Transplant Oncology and Cancer Nursing Care; https://dx.doi.org/10.3390/cancers13061385 |
| DOI: |
10.3390/cancers13061385 |
| الاتاحة: |
https://doi.org/10.3390/cancers13061385 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.3190372B |
| قاعدة البيانات: |
BASE |