التفاصيل البيبلوغرافية
| العنوان: |
Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived Streptomyces sp. |
| المؤلفون: |
Md. Rokon Ul Karim (8600052), Yasuko In (1934056), Tao Zhou (117050), Enjuro Harunari (2143258), Naoya Oku (1715080), Yasuhiro Igarashi (636371) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Physiology, Pharmacology, Biotechnology, Inorganic Chemistry, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, acid residues, compound, Nyuzenamide, antifungal activity, acyl units, Bicyclic Peptides, Marine-Derived Streptomyces sp, Antifungal, sea water, chromatography, chiral-phase, X-ray crystallography, method, mass spectrometry analyses, combination, Cytotoxic Activity, P 388 murine leukemia cells, cytotoxicity, fungi, matter, resonance |
| الوصف: |
Two bicyclic peptides, nyuzenamides A ( 1 ) and B ( 2 ), were discovered from Streptomyces isolated from suspended matter in deep sea water collected in the Sea of Japan. Their structures were determined through nuclear magnetic resonance and mass spectrometry analyses in combination with X-ray crystallography and the chiral-phase gas chromatography–mass spectrometry method to comprise ten amino acid residues containing four unusual amino acids along with aromatic acyl units. Both compounds displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Nyuzenamides_A_and_B_Bicyclic_Peptides_with_Antifungal_and_Cytotoxic_Activity_from_a_Marine-Derived_i_Streptomyces_i_sp_/14166755 |
| DOI: |
10.1021/acs.orglett.1c00210.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.orglett.1c00210.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.317AC9C3 |
| قاعدة البيانات: |
BASE |