Academic Journal
Synthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureas
| العنوان: | Synthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureas |
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| المؤلفون: | Rodríguez Ferrer, Patricia, Sanz Novo, Miguel, Maestro Fernández, Alicia, Andrés García, José María, Pedrosa Sáez, Rafael |
| بيانات النشر: | Wiley Online Library |
| سنة النشر: | 2019 |
| المجموعة: | UVaDOC - Repositorio Documental de la Universidad de Valladolid |
| مصطلحات موضوعية: | Catálisis asimétrica, Asymmetric catalysis, 3-Amino-oxindoles, Pirazoles quirales, Chiral pyrazoles, Tioureas bifuncionales, Bifunctional thioureas, Reacción de Mannich, Mannich reaction |
| الوصف: | Producción Científica ; Enantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative. ; Ministerio de Economía, Industria y Competitividad (Project FEDER-CTQ2014–59870-P) ; Junta de Castilla y León (Projects FEDER-VA115P17 / VA149G18) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1615-4169 |
| Relation: | https://doi.org/10.1002/adsc.201900414; Advanced Synthesis and Catalysis, 2019, vol. 361, n. 15. p. 3645-3655; http://uvadoc.uva.es/handle/10324/37719 |
| DOI: | 10.1002/adsc.201900414 |
| الاتاحة: | http://uvadoc.uva.es/handle/10324/37719 https://doi.org/10.1002/adsc.201900414 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; © 2019 Wiley-VCH |
| رقم الانضمام: | edsbas.314C5347 |
| قاعدة البيانات: | BASE |
| تدمد: | 16154169 |
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| DOI: | 10.1002/adsc.201900414 |