التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation.pdf |
| المؤلفون: |
Chloé Michaudel, Florent Bataille, Isabelle Maillet, Louis Fauconnier, Cyril Colas, Harry Sokol, Marjolène Straube, Aurélie Couturier-Maillard, Laure Dumoutier, Jacques van Snick, Valérie F. Quesniaux, Dieudonnée Togbe, Bernhard Ryffel |
| سنة النشر: |
2020 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, ozone, AhR, ILC3, T cells, inflammation, IL-17, IL-22 |
| الوصف: |
Airborne ozone exposure causes severe lung injury and inflammation. The aryl hydrocarbon Receptor (AhR) (1), activated in pollutant-induced inflammation, is critical for cytokine production, especially IL-22 and IL-17A. The role of AhR in ozone-induced lung inflammation is unknown. We report here that chronic ozone exposure activates AhR with increased tryptophan and lipoxin A4 production in mice. AhR −/− mice show increased lung inflammation, airway hyperresponsiveness, and tissue remodeling with an increased recruitment of IL-17A and IL-22-expressing cells in comparison to control mice. IL-17A- and IL-22-neutralizing antibodies attenuate lung inflammation in AhR −/− and control mice. Enhanced lung inflammation and recruitment of ILC3, ILC2, and T cells were observed after T cell-specific AhR depletion using the AhR CD4cre -deficient mice. Together, the data demonstrate that ozone exposure activates AhR, which controls lung inflammation, airway hyperresponsiveness, and tissue remodeling via the reduction of IL-22 expression. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Data_Sheet_1_Ozone-Induced_Aryl_Hydrocarbon_Receptor_Activation_Controls_Lung_Inflammation_via_Interleukin-22_Modulation_pdf/11897841 |
| DOI: |
10.3389/fimmu.2020.00144.s001 |
| الاتاحة: |
https://doi.org/10.3389/fimmu.2020.00144.s001
https://figshare.com/articles/dataset/Data_Sheet_1_Ozone-Induced_Aryl_Hydrocarbon_Receptor_Activation_Controls_Lung_Inflammation_via_Interleukin-22_Modulation_pdf/11897841 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.31216AAF |
| قاعدة البيانات: |
BASE |