التفاصيل البيبلوغرافية
| العنوان: |
Effect of Spirulina (Formerly Arthrospira) Maxima against Ethanol-Induced Damage in Rat Liver |
| المؤلفون: |
Angélica Pérez-Juárez, José Leopoldo Aguilar-Faisal, Araceli Posadas-Mondragón, José Angel Santiago-Cruz, Cornelio Barrientos-Alvarado, María Angélica Mojica-Villegas, Germán Alberto Chamorro-Cevallos, José A. Morales-González |
| المصدر: |
Applied Sciences; Volume 12; Issue 17; Pages: 8626 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
antioxidant, ethanol, liver, protective effect, Spirulina (formerly Arthrospira) maxima |
| جغرافية الموضوع: |
agris |
| الوصف: |
Spirulina (formerly Arthrospira) maxima (SP) is a cyanobacterium reported to have great nutritional and pharmacological potential. The objective of this study was to evaluate the protective properties of SP against ethanol-induced toxicity. Male Wistar rats were used in the study and subjected to a 70% partial hepatectomy (PH); they were then divided into five groups. During the experiment, animals in two groups drank an aqueous solution of ethanol (EtOH) (40%, v/v). Additionally, they were administered an SP extract daily at a dose of 200 mg/kg body weight intragastrically. To explore possible mechanisms of action, we examined antioxidant defense enzymes, as well as serum biochemical parameters and histopathological changes in the liver. SP administration normalized elevated glutathione reductase (GR), glutathione (GSH), and superoxide dismutase (SOD) levels, in addition to increased catalase (CAT) and glutathione peroxidase (GPX) enzymes. Alterations in biochemical parameters were observed in the groups with PH treated with EtOH associated with a reduction in cholesterol and albumin levels, while glucose and triglyceride levels increased. The histological study supported the protective activity of SP, reducing apoptosis, necrosis, and congestion in the liver. Our findings demonstrated a protective effect of SP against EtOH that is related to less inflammation, a lesser antioxidant effect, and less free radical scavenging activity. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Chemical and Molecular Sciences; https://dx.doi.org/10.3390/app12178626 |
| DOI: |
10.3390/app12178626 |
| الاتاحة: |
https://doi.org/10.3390/app12178626 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.3105800 |
| قاعدة البيانات: |
BASE |