Academic Journal
STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles
| العنوان: | STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles |
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| المؤلفون: | Triantafilou, Kathy, Szomolay, Barbara, Shepherd, Mark William, Ramanjulu, Joshi, Triantafilou, Martha |
| المساهمون: | Parks, Griffith |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| الوصف: | Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enable viral replication. We have recently uncovered a novel non-canonical function of the stimulator of interferon genes (STING) pathway, as a critical factor in the formation of ROs in response to HRV infection. The STING pathway is the main DNA virus sensing system of the innate immune system controlling the type I IFN machinery. Although it is well-characterised as part of the DNA sensor machinery, the STING function in RNA viral infections is largely unexplored. In the current study, we investigated whether other RO-forming RNA viruses, such as EV-D68 and SARS-CoV-2, can also utilise STING for their replication. Using genetic and pharmacological inhibition, we demonstrate that STING is hijacked by these viruses and is utilised as part of the viral replication machinery. STING also co-localises with glycolytic enzymes needed to fuel the energy for replication. The inhibition of STING leads to the modulation of glucose metabolism in EV-D68-infected cells, suggesting that it might also manipulate immunometabolism. Therefore, for RO-generating RNA viruses, STING seems to have non-canonical functions in membrane lipid re-modelling, and the formation of replication vesicles, as well as immunometabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/172952/1/viruses-16-01541.pdf; Triantafilou, Kathy https://orca.cardiff.ac.uk/view/cardiffauthors/A217309Y.html orcid:0000-0002-7473-6278 orcid:0000-0002-7473-6278, Szomolay, Barbara https://orca.cardiff.ac.uk/view/cardiffauthors/A21955378.html orcid:0000-0002-5375-5533 orcid:0000-0002-5375-5533, Shepherd, Mark William https://orca.cardiff.ac.uk/view/cardiffauthors/A2659369F.html, Ramanjulu, Joshi and Triantafilou, Martha https://orca.cardiff.ac.uk/view/cardiffauthors/A2173080.html orcid:0000-0002-8489-2602 orcid:0000-0002-8489-2602 2024. STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles. Viruses 16 (10) , 1541. 10.3390/v16101541 https://doi.org/10.3390/v16101541 file https://orca.cardiff.ac.uk/id/eprint/172952/1/viruses-16-01541.pdf |
| DOI: | 10.3390/v16101541 |
| الاتاحة: | https://orca.cardiff.ac.uk/id/eprint/172952/ https://doi.org/10.3390/v16101541 |
| Rights: | cc_by_4_0 |
| رقم الانضمام: | edsbas.30ED7457 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/v16101541 |
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