Academic Journal
Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in insulin secretion rather than pancreatic β-cell area
| العنوان: | Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in insulin secretion rather than pancreatic β-cell area |
|---|---|
| المؤلفون: | Breuer, Thomas G K, Menge, Bjoern A, Banasch, Matthias, Uhl, Waldemar, Tannapfel, Andrea, Schmidt, Wolfgang E, Nauck, Michael A, Meier, Juris J |
| المصدر: | European Journal of Endocrinology ; volume 163, issue 4, page 551-558 ; ISSN 0804-4643 1479-683X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2010 |
| الوصف: | Introduction Hyperproinsulinaemia has been reported in patients with type 2 diabetes. It is unclear whether this is due to an intrinsic defect in β-cell function or secondary to the increased demand on the β-cells. We investigated whether hyperproinsulinaemia is also present in patients with secondary diabetes, and whether proinsulin levels are associated with impaired β-cell area or function. Patients and methods Thirty-three patients with and without diabetes secondary to pancreatic diseases were studied prior to pancreatic surgery. Intact and total proinsulin levels were compared with the pancreatic β-cell area and measures of insulin secretion and action. Results Fasting concentrations of total and intact proinsulin were similar in patients with normal, impaired (including two cases of impaired fasting glucose) and diabetic glucose tolerance ( P =0.58 and P =0.98 respectively). There were no differences in the total proinsulin/insulin or intact proinsulin/insulin ratio between the groups ( P =0.23 and P =0.71 respectively). There was a weak inverse association between the total proinsulin/insulin ratio and pancreatic β-cell area ( r 2 =0.14, P =0.032), whereas the intact proinsulin/insulin ratio and the intact and total proinsulin levels were unrelated to β-cell area. However, a strong inverse relationship between homeostasis model assessment index of β-cell function and both the total and the intact proinsulin/insulin ratio was found ( r 2 =0.55 and r 2 =0.48 respectively). The association of insulin resistance (IR) with intact proinsulin was much weaker than the correlation with fasting insulin. Conclusions Hyperproinsulinaemia is associated with defects in insulin secretion rather than a reduction in β-cell area. The weak association between intact proinsulin and IR argues against the usefulness of this parameter in clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/eje-10-0330 |
| الاتاحة: | http://dx.doi.org/10.1530/eje-10-0330 https://eje.bioscientifica.com/view/journals/eje/163/4/551.xml |
| رقم الانضمام: | edsbas.30D8FF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/eje-10-0330 |
|---|