Academic Journal
A Concise Synthesis of Presilphiperfolane Core through a Tandem TMTU-Co-Catalyzed Pauson-Khand Reaction and a 6 pi Electrocyclization Reaction (TMTU=Tetramethyl Thiourea)
| العنوان: | A Concise Synthesis of Presilphiperfolane Core through a Tandem TMTU-Co-Catalyzed Pauson-Khand Reaction and a 6 pi Electrocyclization Reaction (TMTU=Tetramethyl Thiourea) |
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| المؤلفون: | Zhang, Zichun, Li, Yuanhe, Zhao, Dandan, He, Yingdong, Gong, Jianxian, Yang, Zhen |
| المساهمون: | Gong, JX (reprint author), Peking Univ Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Peoples R China., Peking Univ Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Peoples R China., Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China., Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn Minist Educ, Beijing 100871, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | CHEMISTRY-A EUROPEAN JOURNAL |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | electrocyclic reactions, tandem reaction, Pauson-Khand reaction, presilphiperfolane core, total synthesis, OCCURRING TERPENE DERIVATIVES, ENDIANDRIC ACID CASCADE, STEREOCONTROLLED TOTAL-SYNTHESIS, ENANTIOSELECTIVE SYNTHESIS, ORGANIC-SYNTHESIS, ESSENTIAL OIL, BIOMIMETIC APPROACH, ENZYMATIC FORMATION, NATURAL-PRODUCTS, SESQUITERPENES |
| الوصف: | The synthesis of strained polycyclic systems from readily available precursors with a minimum number of steps and with regio-and stereochemical control constitutes an important synthetic challenge. Herein, we report a tandem reaction comprising Co-TMTU (tetramethyl thiourea)-catalyzed Pauson-Khand (PK) and 6pelectrocyclization reactions for the formation of the highly strained core of presilphiperfolanols. The developed chemistry has been applied to the total syntheses of 4epi- presilphiperfolan-8-ol and 7-epi-presilphiperfolan-1-ol. ; National Science Foundation of China [21372016, 21572009, 21402002]; Guangdong Natural Science Foundation [2014A030312004, 2016A03030601]; NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402] ; SCI(E) ; ARTICLE ; 6 ; 1258-1262 ; 23 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0947-6539 1521-3765 |
| Relation: | CHEMISTRY-A EUROPEAN JOURNAL.2017,23(6),1258-1262.; 1910932; http://hdl.handle.net/20.500.11897/476274; WOS:000395753300008 |
| DOI: | 10.1002/chem.201605438 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/476274 https://doi.org/10.1002/chem.201605438 |
| رقم الانضمام: | edsbas.30924597 |
| قاعدة البيانات: | BASE |
| تدمد: | 09476539 15213765 |
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| DOI: | 10.1002/chem.201605438 |