Academic Journal
Involvement of a 43-kilodalton outer membrane protein in -lactam resistance of Shigella dysenteriae
| العنوان: | Involvement of a 43-kilodalton outer membrane protein in -lactam resistance of Shigella dysenteriae |
|---|---|
| المؤلفون: | Alak Kanti Kar, Anindya Sundar Ghosh, Kamlesh Chauhan, Jasimuddin Ahamed |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://aac.asm.org/content/41/10/2302.full.pdf. |
| سنة النشر: | 1997 |
| المجموعة: | CiteSeerX |
| الوصف: | A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with Mrs of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 was lower than that across the OM of C152. Mutants deficient in the 43-kDa OMP could be selected in vitro from strain C152 in the presence of cefoxitin. All beta-lactam-resistant strains were sensitive to imipenem. Shigella species represent a major cause of diarrheal diseases in developing countries (2). The frequency of strains multiply resistant to ampicillin, trimethoprim-sulfamethoxazole, strep-tomycin, chloramphenicol, and tetracycline is a cause of grow-ing concern (2, 4). Resistance to antibiotics may arise through alteration of the drug targets (26), degradation of the drugs by enzymes such as the beta-lactamases (10), decrease in perme-ability of the cell envelope (8, 9, 14, 16, 23, 25), and extrusion of the drugs by efflux pumps of broad specificity (17). The permeability factor controlling the access of the antibiotic to its |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1000.4612; http://aac.asm.org/content/41/10/2302.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1000.4612 http://aac.asm.org/content/41/10/2302.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.30903947 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |