Academic Journal
Oxidative stress in severe acute illness
| العنوان: | Oxidative stress in severe acute illness |
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| المؤلفون: | David Bar-Or, Raphael Bar-Or, Leonard T. Rael, Edward N. Brody |
| المصدر: | Redox Biology, Vol 4, Iss C, Pp 340-345 (2015) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Malondialdehyde, 4-Hydroxynonenal, Oxidation reduction potential, Traumatic brain injury, Superoxide dismutase, Hypoxia-inducible factor 1, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including glutathione–glutathione disulfide, reduced thioredoxin–oxidized thioredoxin, and NAD+–NADH (and NADP–NADPH). Current methods for evaluating oxidative stress rely on detecting levels of individual byproducts of oxidative damage or by determining the total levels or activity of individual antioxidant enzymes. Oxidation–reduction potential (ORP), on the other hand, is an integrated, comprehensive measure of the balance between total (known and unknown) pro-oxidant and antioxidant components in a biological system. Much emphasis has been placed on the role of oxidative stress in chronic diseases, such as Alzheimer's disease and atherosclerosis. The role of oxidative stress in acute diseases often seen in the emergency room and intensive care unit is considerable. New tools for the rapid, inexpensive measurement of both redox potential and total redox capacity should aid in introducing a new body of literature on the role of oxidative stress in acute illness and how to screen and monitor for potentially beneficial pharmacologic agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231715000075; https://doaj.org/toc/2213-2317; https://doaj.org/article/da0d15d7ee8142e7926655d4d1cc7256 |
| DOI: | 10.1016/j.redox.2015.01.006 |
| الاتاحة: | https://doi.org/10.1016/j.redox.2015.01.006 https://doaj.org/article/da0d15d7ee8142e7926655d4d1cc7256 |
| رقم الانضمام: | edsbas.3068FA21 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2015.01.006 |