التفاصيل البيبلوغرافية
| العنوان: |
Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients |
| المؤلفون: |
Crnko, Sandra, Printezi, Markella I, Jansen, Tijn P J, Leiteris, Laurynas, van der Meer, Manon G, Schutte, Hilde, van Faassen, Martijn, du Pré, Bastiaan C, de Jonge, Nicolaas, Asselbergs, Folkert W, Gaillard, Carlo A J M, Kemperman, Hans, Doevendans, Pieter A, Sluijter, Joost P G, van Laake, Linda W |
| المساهمون: |
Team Onderzoek, Regenerative Medicine and Stem Cells, Team Medisch, Circulatory Health, DIGD-Medisch 1, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Onderzoek Cardiovasculair Reg. Med. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Biomarker, Circadian rhythm, Diurnal rhythm, Heart failure, NT-proBNP, sST2, Cardiology and Cardiovascular Medicine, Journal Article |
| الوصف: |
AIM: Soluble suppression of tumorigenicity-2 (sST2) is a strong prognostic biomarker in heart failure. The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease-biomarker interaction. So far, it is unknown whether sST2 exhibits a diurnal rhythm. Repeated measurements of sST2 may aid in clinical decision making. The goal of this study was to investigate whether sST2 exhibits diurnal variation in patients with heart failure with reduced ejection fraction (HFrEF) and in control subjects, thereby enhancing its diagnostic and prognostic values. METHODS AND RESULTS: The study comprised 32 subjects: 16 HFrEF patients and 16 controls. Blood was collected at seven subsequent time points during a 24 h time period. sST2, N-terminal pro-B-type natriuretic peptide (NT-proBNP), melatonin, and cortisol were measured from serum. Peak values of sST2 clustered at daytime (modal value: 5 p.m.) in 87.6% of all subjects (81.3% of patients, P = 0.021; 93.8% of controls, P = 0.001), and minimum concentrations at night-time (modal value: 5 a.m.) in 84.4% (87.5% of patients, P = 0.004 81.3% of controls, P = 0.021). A cosinor analysis of mean normalized sST2 values revealed significant cosine shaped 24 h oscillations of patients (P = 0.026) and controls (P = 0.037). NT-proBNP in contrast did not show a diurnal rhythm, while melatonin and cortisol patterns were intact in all subjects. CONCLUSIONS: sST2 exhibits a diurnal rhythm with lower values in the morning than in the late afternoon. This new insight could lead to refinement of its diagnostic and prognostic values through specified and consistent sampling times with repeated measurements. For example, by measuring sST2 during the afternoon, when levels are at their highest, false negatives on prognosis prediction could be avoided. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2055-5822 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/439779 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/439779 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.303361DE |
| قاعدة البيانات: |
BASE |
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