Academic Journal
Antiviral Properties of Prodelphinidin B-2 3′- O-Gallate from Green Tea Leaf
| العنوان: | Antiviral Properties of Prodelphinidin B-2 3′- O-Gallate from Green Tea Leaf |
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| المؤلفون: | Cheng, Hua-Yew, Lin, Chun-Ching, Lin, Ta-Chen |
| المصدر: | Antiviral Chemistry and Chemotherapy ; volume 13, issue 4, page 223-229 ; ISSN 2040-2066 2040-2066 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2002 |
| الوصف: | Prodelphinidin B-2 3′-O-gallate, a proanthocyanidin gallate isolated from green tea leaf, was investigated for its anti-herpes simplex virus type 2 properties in vitro. Prodelphinidin B-2 3′- O-gallate exhibited antiviral activity with IC 50 of 5.0 ± 1.0 μM and 1.6 ± 0.3 μM for XTT and plaque reduction (PRA) assays, respectively. Cytotoxicity assay had shown that prodelphinidin B-2 3′- O-gallate possessed cytotoxic effect toward Vero cell at concentration higher than its IC 50 . The 50% cytotoxic concentration for cell growth (CC 50 ) was 33.3 ± 3.7 μM. Thus, the selectivity index (SI) (ratio of IC 50 to CC 50 ) for XTT assay and PRA was 6.7 and 20.8, respectively. Prodelphinidin B-2 3′- O-gallate significantly reduced viral infectivity at concentrations 10 μM or more. Result of time-of-addition studies suggested that prodelphinidin B-2 3′- O-gallate affected the late stage of HSV-2 infection. In addition, it was also shown to inhibit the virus from attaching and penetrating into the cell. Thus, prodelphinidin B-2 3′- O-gallate was concluded to possess antiviral activity with mechanism of inhibiting viral attachment and penetration, and disturbing the late stage of viral infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/095632020201300403 |
| الاتاحة: | http://dx.doi.org/10.1177/095632020201300403 http://journals.sagepub.com/doi/pdf/10.1177/095632020201300403 |
| Rights: | http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.30226854 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/095632020201300403 |
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