Academic Journal
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man
| العنوان: | Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man |
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| المؤلفون: | Barnes, E, Folgori, A, Capone, S, Swadling, L, Aston, S, Kurioka, A, Meyer, J, Huddart, R, Smith, K, Townsend, R, Brown, A, Antrobus, R, Ammendola, V, Naddeo, M, O'Hara, G, Willberg, C, Harrison, A, Grazioli, F, Esposito, M, Siani, L, Traboni, C, Oo, Y, Adams, D, Hill, A, Colloca, S, Nicosia, A, Cortese, R, Klenerman, P |
| بيانات النشر: | American Association for the Advancement of Science |
| سنة النشر: | 2017 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally. Many studies suggest that host T cell responses are critical for spontaneous resolution of disease, and preclinical studies have indicated a requirement for T cells in protection against challenge. We aimed to elicit HCV-specific T cells with the potential for protection using a recombinant adenoviral vector strategy in a phase 1 study of healthy human volunteers. Two adenoviral vectors expressing NS proteins from HCV genotype 1B were constructed based on rare serotypes [human adenovirus 6 (Ad6) and chimpanzee adenovirus 3 (ChAd3)]. Both vectors primed T cell responses against HCV proteins; these T cell responses targeted multiple proteins and were capable of recognizing heterologous strains (genotypes 1A and 3A). HCV-specific T cells consisted of both CD4 + and CD8 + T cell subsets; secreted interleukin-2, interferon-γ, and tumor necrosis factor-α; and could be sustained for at least a year after boosting with the heterologous adenoviral vector. Studies using major histocompatibility complex peptide tetramers revealed long-lived central and effector memory pools that retained polyfunctionality and proliferative capacity. These data indicate that an adenoviral vector strategy can induce sustained T cell responses of a magnitude and quality associated with protective immunity and open the way for studies of prophylactic and therapeutic vaccines for HCV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ora.ox.ac.uk/objects/uuid:bb2adf4e-420e-4d2a-997e-016e90170f15; https://doi.org/10.1126/scitranslmed.3003155 |
| DOI: | 10.1126/scitranslmed.3003155 |
| الاتاحة: | https://doi.org/10.1126/scitranslmed.3003155 https://ora.ox.ac.uk/objects/uuid:bb2adf4e-420e-4d2a-997e-016e90170f15 |
| Rights: | info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.3017C495 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/scitranslmed.3003155 |
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