التفاصيل البيبلوغرافية
| العنوان: |
Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats |
| المؤلفون: |
Duan, Yin, Lockwood, Julia, Wei, Lihui, Hunter, Chad, Soueidan, Karen, Bensimon, Corinne, Fernando, Pasan, Wells, R, Ruddy, Terrence D |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2014 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
123I-CMICE-013, Myocardial perfusion imaging, Biodistribution, Radiodosimetry, Quantitative SPECT imaging |
| الوصف: |
Background 123 I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and radiodosimetry of this rotenone-like 123 I-labeled tracer in a microSPECT imaging-based study. Methods 37 to 111 MBq of 123 I-CMICE-013 was synthesized and administered intravenously to 14 healthy rats. Images were acquired with a microSPECT/CT camera at various time intervals and reconstructed to allow activity quantification in the tissues of interest. Radiation dosage resulted from the injection of 123 I-CMICE-013 was estimated base on the biodistribution data. Tissue uptake values from image analysis were verified by gamma-counting dissected organs ex vivo . Results The heart/stomach and heart/intestine uptake ratios peaked shortly after the injection of 123 I-CMICE-013, meanwhile the heart/liver ratio reached 2 as early as at 23 min post-injection. Little activity was observed in the lung and overnight clearance was significant in most of the measured tissues. The radiation dosimetry analysis based on the time-activity curves provided an estimate of the effective human dose of 6.99E-03 mSv/MBq using ICRP 60 and 7.15E-03 mSv/MBq using ICRP 103, which is comparable to the popular myocardium perfusion imaging (MPI) agents such as 99m Tc-tetrofosmin and 99m Tc-sestamibi, as well as other 123 I-based radiotracers. Conclusions 123 I-CMICE-013 demonstrated desirable characteristics in its biokinetic and radiodosimetric profiles, supporting its potential application as a novel myocardial perfusion imaging agent. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
http://www.ejnmmires.com/content/4/1/16 |
| الاتاحة: |
http://www.ejnmmires.com/content/4/1/16 |
| Rights: |
Copyright 2014 Duan et al.; licensee Springer. |
| رقم الانضمام: |
edsbas.300D4A0D |
| قاعدة البيانات: |
BASE |