Academic Journal
AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker
| العنوان: | AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker |
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| المؤلفون: | Ma, Jun, Luo, Di-Xian, Huang, Chenfei, Shen, Yi, Bu, Yiwen, Markwell, Stephen, Gao, John, Liu, Jianghua, Zu, Xuyu, Cao, Zhe, Gao, Zachary, Lu, Fengmin, Liao, Duan-Fang, Cao, Deliang |
| المساهمون: | Cao, DL (reprint author), So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA., So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA., First Peoples Hosp Chenzhou, Inst Translat Med, Chenzhou 423000, Peoples R China., So Illinois Univ, Sch Med, Div Stat & Res Consulting, Springfield, IL 62794 USA., Mem Med Ctr, Dept Pathol, Springfield, IL 62702 USA., Univ S China, Inst Pharm & Pharmacol, Coll Pharm & Life Sci, Hengyang 421001, Peoples R China., Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100083, Peoples R China., Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Beijing 100083, Peoples R China., Univ S China, Affiliated Hosp 1, Hengyang 421001, Peoples R China., Hunan Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Diagnost, Changsha 420108, Hunan, Peoples R China., So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA. |
| المصدر: | SCI |
| بيانات النشر: | international journal of cancer |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | aldo-keto reductase 1B10, breast cancer, disease-related survival, prognostic marker, serum marker, KETO REDUCTASE FAMILY, HUMAN ALDOSE REDUCTASE, FATTY-ACID SYNTHASE, LUNG-CANCER, EXPRESSION, B10, MEMBER, CELLS, HER-2, IDENTIFICATION |
| الوصف: | Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated with tumorigenic transformation of human mammary epithelial cells. This study demonstrated that AKR1B10 was overexpressed in 20 (71.4%) of 28 ductal carcinomas in situ, 184 (83.6%) of 220 infiltrating carcinomas and 28 (87.5%) of 32 recurrent tumors. AKR1B10 expression in breast cancer was correlated positively with tumor size (p = 0.0012) and lymph node metastasis (p = 0.0123) but inversely with disease-related survival (p = 0.0120). Univariate (p = 0.0077) and multivariate (p = 0.0192) analyses both suggested that AKR1B10, alone or together with tumor size and node status, is a significant prognostic factor for breast cancer. Silencing of AKR1B10 in BT-20 human breast cancer cells inhibited cell growth in culture and tumorigenesis in female nude mice. Importantly, AKR1B10 in the serum of breast cancer patients was significantly increased to 15.18 +/- 9.08 ng/ml [n = 50; 95% confidence interval (CI), 12.6017.76], with a high level up to 58.4 ng/ml, compared to 3.34 +/- 2.27 ng/ml in healthy donors (n = 60; 95% CI, 2.783.90). In these patients, AKR1B10 levels in serum were correlated with its expression in tumors (r = 0.8066; p < 0.0001). Together our data suggests that AKR1B10 is overexpressed in breast cancer and may be a novel prognostic factor and serum marker for this deadly disease. ; Oncology ; SCI(E) ; 15 ; ARTICLE ; 6 ; E862-E871 ; 131 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0020-7136 1097-0215 |
| Relation: | INTERNATIONAL JOURNAL OF CANCER.2012,131,(6),E862-E871.; 865074; http://hdl.handle.net/20.500.11897/230793; WOS:000306735700002 |
| DOI: | 10.1002/ijc.27618 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/230793 https://doi.org/10.1002/ijc.27618 |
| رقم الانضمام: | edsbas.300C2550 |
| قاعدة البيانات: | BASE |
| تدمد: | 00207136 10970215 |
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| DOI: | 10.1002/ijc.27618 |