Academic Journal
Differential Characteristics and Prognosis of PD-L1–Positive Endometrial Carcinomas: A Retrospective Chart Review
| العنوان: | Differential Characteristics and Prognosis of PD-L1–Positive Endometrial Carcinomas: A Retrospective Chart Review |
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| المؤلفون: | Justin Z. Amarin, Razan Mansour, Sura Al-Ghnimat, Maysa Al-Hussaini |
| المصدر: | Life, Vol 11, Iss 1047, p 1047 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | DNA mismatch repair, endometrial carcinoma, immunohistochemistry, programmed cell death 1 ligand 1 (PD-L1), Science |
| الوصف: | Women with endometrial carcinomas that express PD-L1 may respond better to immunotherapy. Our aim was to investigate the differential characteristics of PD-L1–positive endometrial carcinomas and the prognostic significance of PD-L1. We performed a retrospective chart review of 231 women with endometrial carcinomas who were managed at King Hussein Cancer Center (2007–2016) and performed immunohistochemistry for MLH1, PMS2, MSH2, MSH6, p53, and PD-L1. Overall, 89 cases (38.5%) were MMR-deficient. PD-L1 was expressed in 49 cases (21.2%) and its expression was significantly associated with MLH1/PMS2 deficiency ( p = 0.044) but not MSH2/MSH6 deficiency ( p = 0.59). p53 was mutant in 106 cases (46.5%), and its mutation was significantly associated with MMR proficiency ( p < 0.001) but not PD-L1 expression ( p = 0.78). In women with endometrioid adenocarcinomas, PD-L1 expression was significantly associated with the Fédération Internationale de Gynécologie et d′Obstétrique (FIGO) grade ( p = 0.008). Overall, PD-L1 expression did not significantly predict overall survival in unadjusted or adjusted analyses ( p = 0.92 and 0.54, respectively). In conclusion, tumors with MLH1/PMS2 loss and high-grade endometrioid adenocarcinomas were more likely to express PD-L1 in tumor cells. Further research is required to investigate whether the presence of either characteristic signals a higher likelihood of a favorable response if immunotherapy is administered. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2075-1729 |
| Relation: | https://www.mdpi.com/2075-1729/11/10/1047; https://doaj.org/toc/2075-1729; https://doaj.org/article/41b89bffef2d48b9ab84f25ab5c6b273 |
| DOI: | 10.3390/life11101047 |
| الاتاحة: | https://doi.org/10.3390/life11101047 https://doaj.org/article/41b89bffef2d48b9ab84f25ab5c6b273 |
| رقم الانضمام: | edsbas.30098FCF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20751729 |
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| DOI: | 10.3390/life11101047 |