Academic Journal
Regional differences in expression of TPH‐1, SERT, 5‐HT 3 and 5‐HT 4 receptors in the human stomach and duodenum
| العنوان: | Regional differences in expression of TPH‐1, SERT, 5‐HT 3 and 5‐HT 4 receptors in the human stomach and duodenum |
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| المؤلفون: | Van Lelyveld, N., Ter Linde, J., Schipper, M. E. I., Samsom, M. |
| المصدر: | Neurogastroenterology & Motility ; volume 19, issue 5, page 342-348 ; ISSN 1350-1925 1365-2982 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2007 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The aim of this study was to increase the understanding of the role of serotonergic signalling in normal gastroduodenal function at a molecular level. Mucosal biopsy specimens were collected from the fundus, antrum and duodenum of 11 healthy subjects. Serotonin (5‐HT)‐positive cells were counted and the mRNA levels of tryptophan hydroxylase (TPH), serotonin transporter (SERT), 5‐HT 4 receptor and 5‐HT 3 receptor subunits were quantified by real‐time reverse transcription polymerase chain reaction. The number of 5‐HT‐positive cells was larger in the duodenum compared with the stomach ( P < 0.001). Serotonin transport protein expression was 19‐fold higher in the duodenum compared with the antrum and 457‐fold higher compared with the fundus ( P < 0.001). Tryptophan hydroxylase‐1 expression was lower in the duodenum compared with the antrum and fundus (regional differences −2.3 and −3.6, respectively). The 5‐HT 4 receptor and the 5‐HT 3C and 5‐HT 3E receptor subunits were more abundantly expressed in duodenum compared with the stomach ( P < 0.001). The larger number of 5‐HT‐positive cells, the higher expression of 5‐HT 3 and 5‐HT 4 receptors, and in particularly the higher uptake capacity of 5‐HT in the duodenum, point out to a more prominent role of serotonergic signalling at the mucosal level in the duodenum compared with the stomach. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-2982.2006.00891.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-2982.2006.00891.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2982.2006.00891.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2982.2006.00891.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.2FE67250 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-2982.2006.00891.x |
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