التفاصيل البيبلوغرافية
| العنوان: |
Local ancestry across the MHC. |
| المؤلفون: |
Ashley H. Beecham (14294973), Lilyana Amezcua (479974), Angel Chinea (6053873), Clara P. Manrique (6053858), Lissette Gomez (10704356), Andrea Martinez (2622652), Gary W. Beecham (13002075), Nikolaos A. Patsopoulos (7157525), Tanuja Chitnis (236410), Howard L. Weiner (10529078), Philip L. De Jager (7208123), Esteban G. Burchard (8724966), Brett T. Lund (8976071), Kathryn C. Fitzgerald (8762136), Peter A. Calabresi (7354271), Silvia R. Delgado (14294976), Jorge R. Oksenberg (9512030), Jacob L. McCauley (8570838) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Genetics, Biotechnology, Evolutionary Biology, Ecology, Sociology, Immunology, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, major histocompatibility complex, largest genetic contribution, correlated environmental factors, almost two times, allele frequency differences, indicate ancestral differences, european allele carriers, african allele carriers, region explaining 20, native american ancestry, high across populations, african american individuals, div >< p, ancestral risk modification, investigating ms susceptibility, european populations including, european populations, ancestral level, african americans, local ancestry |
| الوصف: |
A. Association with MS case status. p-values from the likelihood ratio test for the effect of local ancestry on MS case status are depicted on the Y-axis and position in MB (HG19) on the x-axis. We find association of local ancestry with MS case status (p < 0.05, i.e. -log10P = 1.3) across the entire MHC in Hispanics, but no significance is observed at the same threshold in African Americans. B. Average percent change in local vs global ancestry for Hispanic cases and controls. An increase in African local ancestry and a decrease in European local ancestry relative to global ancestry is observed in both MS cases and controls across the entire region, consistent with admixture-enabled selection [ 31 ]. On average, Hispanic controls exhibit a greater decrease in European local ancestry relative to global ancestry than MS cases, in conjunction with a marked increase in Native American local ancestry. Differences peak between the class I and class III gene region, corresponding to the increase in -log10P denoted in (A). C. Average percent change in local vs global ancestry for African American cases and controls. Consistent with Hispanics, we observe an increase in African local ancestry and a decrease in European local ancestry relative to global ancestry in MS cases and controls across the entire region. The changes are of consistent magnitude in MS cases and controls, except for ~31 to ~32.6 MB between the class I and class II gene regions, where we see on average that African American controls exhibit a lesser increase in African local ancestry relative to global ancestry than MS cases, again in conjunction with a marked increase in Native American local ancestry (although -log10P does not reach a threshold for significance). |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Local_ancestry_across_the_MHC_/21772134 |
| DOI: |
10.1371/journal.pone.0279132.g003 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0279132.g003 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.2FDDF07F |
| قاعدة البيانات: |
BASE |