Academic Journal
Carnosine, oxidative and carbonyl stress, antioxidants and muscle fiber characteristics of quadriceps muscle of patients with COPD
| العنوان: | Carnosine, oxidative and carbonyl stress, antioxidants and muscle fiber characteristics of quadriceps muscle of patients with COPD |
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| المؤلفون: | de Brandt, Jana, Burtin, Chris, Pomiès, Pascal, Vandenabeele, Frank, Verboven, Kenneth, Aumann, Joseph, Blancquaert, Laura, Everaert, Inge, van Ryckeghem, Lisa, Cops, Jirka, Hayot, Maurice, Spruit, Martijn, Derave, Wim |
| المساهمون: | Hasselt University (UHasselt), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Jessa Ziekenhuis Hasselt, Universiteit Gent = Ghent University = Université de Gand (UGENT), Maastricht University Medical Centre (MUMC), Maastricht University Maastricht |
| المصدر: | ISSN: 8750-7587. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2021 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] |
| الوصف: | International audience ; Background: Oxidative/carbonyl stress is elevated in lower-limb muscles of patients with Chronic Obstructive Pulmonary Disease (COPD). Carnosine is a skeletal muscle antioxidant particularly present in fast-twitch fibers. Aims: To compare muscle carnosine, oxidative/carbonyl stress, antioxidants and fiber characteristics between patients with COPD and healthy controls (HCs), and between patients after stratification for airflow limitation (mild/moderate vs. severe/very-severe). To investigate correlates of carnosine in patients with COPD. Methods: A vastus lateralis muscle biopsy was obtained from 40 patients with stable COPD and 20 age/sex matched HCs. Carnosine, oxidative/carbonyl stress, antioxidants, fiber characteristics, quadriceps strength and endurance (QE), VO 2 peak (incremental cycle test) and physical activity (PA) were determined. Results: Patients with COPD had a similar carnosine concentration (4.16 mmol/kg wet weight (WW) (SD 1.93)) to HCs (4.64 mmol/kgWW (SD 1.71)) and significantly higher percentage of fast-twitch fibers and lower QE, VO 2 peak and PA vs. HCs. Patients with severe/very-severe COPD had a 30% lower carnosine concentration (3.24 mmol/kgWW (SD 1.79); n=15) vs. patients with mild/moderate COPD (4.71 mmol/kgWW (SD 1.83); n=25; P=0.02) and significantly lower VO 2 peak and PA vs. patients with mild/moderate COPD. Carnosine correlated significantly with QE (r s =0.427), VO 2 peak (r s =0.334), PA (r s =0.379) and lung function parameters in patients with COPD. Conclusion: Despite having the highest proportion of fast-twitch fibers, patients with severe/very-severe COPD displayed a 30% lower muscle carnosine concentration compared to patients with mild/moderate COPD. As no oxidative/carbonyl stress markers, nor antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34323590; PUBMED: 34323590; WOS: 000702916400001 |
| DOI: | 10.1152/japplphysiol.00200.2021 |
| الاتاحة: | https://hal.science/hal-03310531 https://hal.science/hal-03310531v1/document https://hal.science/hal-03310531v1/file/2021%20De%20brandt%20et%20al.,%20Carnosine.pdf https://doi.org/10.1152/japplphysiol.00200.2021 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2FC8268C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/japplphysiol.00200.2021 |
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