Academic Journal
Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity ; Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity
| العنوان: | Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity ; Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity |
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| المؤلفون: | Gattu, Sureka, Bang, Ye-Ji, Pendse, Mihir, Dende, Chaitanya, Chara, Andrew L., Harris, Tamia A., Wang, Yuhao, Ruhn, Kelly A., Kuang, Zheng, Sockanathan, Shanthini, Hooper, Lora V. |
| المساهمون: | Bang, Ye-Ji |
| بيانات النشر: | National Academy of Sciences |
| سنة النشر: | 2023 |
| المجموعة: | Seoul National University: S-Space |
| الوصف: | Vitamin A is a dietary component that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here we show that epithelial cell expression of the transcription factor retinoic acid receptor beta (RA beta) is essential for vitamin A-dependent intestinal immunity. Epithelial RAR beta activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. In accordance with the known role of SAAs in regulating Th17 cell effector function, epithelial RAR beta promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RAR beta was required for the development of key vitamin A-dependent adaptive immune responses, including CD4(+) T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Our findings provide insight into how the intestinal epithelium senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial cells in regulating intestinal immunity in response to diet. ; Y ; 1 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0027-8424 |
| Relation: | Proceedings of the National Academy of Sciences of the United States of America, Vol.116 No.22, pp.10911-10916; https://hdl.handle.net/10371/191794; 000469280300051; 2-s2.0-85066233061; 182049 |
| DOI: | 10.1073/pnas.1812069116 |
| الاتاحة: | https://hdl.handle.net/10371/191794 https://doi.org/10.1073/pnas.1812069116 |
| رقم الانضمام: | edsbas.2FC5E434 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00278424 |
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| DOI: | 10.1073/pnas.1812069116 |