التفاصيل البيبلوغرافية
| العنوان: |
Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis |
| المؤلفون: |
Micó, Victor, San-Cristobal, Rodrigo, MartÃn, Roberto, MartÃnez-González, Miguel Ãngel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Alonso-Gómez, Ãngel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. LuÃs, Bueno-Cavanillas, Aurora, Tur, Josep A., MartÃn, Vicente, Pintó, Xavier, Delgado-RodrÃguez, Miguel, MatÃa-MartÃn, Pilar, Vidal, Josep, Vázquez, Clotilde, GarcÃa-Arellano, Ana, Pertusa-Martinez, Salvador, Chaplin, Alice, GarcÃa-Rios, Antonio, Muñoz Bravo, Carlos, Schröder, Helmut, Babio, Nancy, Sorli, Jose V., Gonzalez, Jose I., Martinez-Urbistondo, Diego, Toledo, Estefania, Bullón, Vanessa, Ruiz-Canela, Miguel, Portillo, MarÃa Puy, MacÃas-González, Manuel., Perez-Diaz-del-Campo, Nuria, GarcÃa-Gavilán, Jesús., Daimiel, Lidia, MartÃnez, J Alfredo, Universitat Autònoma de Barcelona |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Biomarkers, Clúster, Dyslipidemia, Glucose disorders, Hepatic enzymes, Metabolic syndrome |
| الوصف: |
Metabolic syndrome (MetS) is one of the most important medical problems around the world. Identification of patient's singular characteristic could help to reduce the clinical impact and facilitate individualized management. This study aimed to categorize MetS patients using phenotypical and clinical variables habitually collected during health check-ups of individuals considered to have high cardiovascular risk. The selected markers to categorize MetS participants included anthropometric variables as well as clinical data, biochemical parameters and prescribed pharmacological treatment. An exploratory factor analysis was carried out with a subsequent hierarchical cluster analysis using the z-scores from factor analysis. The first step identified three different factors. The first was determined by hypercholesterolemia and associated treatments, the second factor exhibited glycemic disorders and accompanying treatments and the third factor was characterized by hepatic enzymes. Subsequently four clusters of patients were identified, where cluster 1 was characterized by glucose disorders and treatments, cluster 2 presented mild MetS, cluster 3 presented exacerbated levels of hepatic enzymes and cluster 4 highlighted cholesterol and its associated treatments Interestingly, the liver status related cluster was characterized by higher protein consumption and cluster 4 with low polyunsaturated fatty acid intake. This research emphasized the potential clinical relevance of hepatic impairments in addition to MetS traditional characterization for precision and personalized management of MetS patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
16642392 |
| Relation: |
Ministerio de EconomÃa y Competitividad PI13/00673; Ministerio de EconomÃa y Competitividad PI13/00492; Ministerio de EconomÃa y Competitividad PI13/00272; Ministerio de EconomÃa y Competitividad PI13/01123; Ministerio de EconomÃa y Competitividad PI13/00462; Ministerio de EconomÃa y Competitividad PI13/00233; Ministerio de EconomÃa y Competitividad PI13/02184; Ministerio de EconomÃa y Competitividad PI13/00728; Ministerio de EconomÃa y Competitividad PI13/01090; Ministerio de EconomÃa y Competitividad PI13/01056; Ministerio de EconomÃa y Competitividad PI14/01722; Ministerio de EconomÃa y Competitividad PI14/00636; Ministerio de EconomÃa y Competitividad PI14/00618; Ministerio de EconomÃa y Competitividad PI14/00696; Ministerio de EconomÃa y Competitividad PI14/01206; Ministerio de EconomÃa y Competitividad PI14/01919; Ministerio de EconomÃa y Competitividad PI14/00853; Ministerio de EconomÃa y Competitividad PI14/01374; Ministerio de EconomÃa y Competitividad PI14/00972; Ministerio de EconomÃa y Competitividad PI14/00728; Ministerio de EconomÃa y Competitividad PI14/01471; Ministerio de EconomÃa y Competitividad PI16/00473; Ministerio de EconomÃa y Competitividad PI16/00662; Ministerio de EconomÃa y Competitividad PI16/01873; Ministerio de EconomÃa y Competitividad PI16/01094; Ministerio de EconomÃa y Competitividad PI16/00501; Ministerio de EconomÃa y Competitividad PI16/00533; Ministerio de EconomÃa y Competitividad PI16/00381; Ministerio de EconomÃa y Competitividad PI16/00366; Ministerio de EconomÃa y Competitividad PI16/01522; Ministerio de EconomÃa y Competitividad PI16/01120; Instituto de Salud Carlos III PI17/00764; Instituto de Salud Carlos III PI17/01183; Instituto de Salud Carlos III PI17/00855; Instituto de Salud Carlos III PI17/01347; Instituto de Salud Carlos III PI17/00525; Instituto de Salud Carlos III PI17/01827; Instituto de Salud Carlos III PI17/00532; Instituto de Salud Carlos III PI17/00215; Instituto de Salud Carlos III PI17/01441; Instituto de Salud Carlos III PI17/00508; Instituto de Salud Carlos III PI17/01732; Instituto de Salud Carlos III PI17/00926; Instituto de Salud Carlos III PI19/00957; Instituto de Salud Carlos III PI19/00386; Instituto de Salud Carlos III PI19/00309; Instituto de Salud Carlos III PI19/01032; Instituto de Salud Carlos III PI19/00576; Instituto de Salud Carlos III PI19/00017; Instituto de Salud Carlos III PI19/01226; Instituto de Salud Carlos III PI19/00781; Instituto de Salud Carlos III PI19/01560; Instituto de Salud Carlos III PI19/01332; Instituto de Salud Carlos III PI20/01802; Instituto de Salud Carlos III PI20/00138; Instituto de Salud Carlos III PI20/01532; Instituto de Salud Carlos III PI20/00456; Instituto de Salud Carlos III PI20/00339; Instituto de Salud Carlos III PI20/00557; Instituto de Salud Carlos III PI20/00886; Instituto de Salud Carlos III PI20/01158; Frontiers in endocrinology; Vol. 13 (june 2022), p. 936956; https://ddd.uab.cat/record/292229; urn:10.3389/fendo.2022.936956; urn:oai:ddd.uab.cat:292229; urn:scopus_id:85138414223; urn:articleid:16642392v13p936956; urn:pmid:36147576; urn:pmc-uid:9487178; urn:pmcid:PMC9487178; urn:oai:pubmedcentral.nih.gov:9487178 |
| الاتاحة: |
https://ddd.uab.cat/record/292229 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.2FC37D4B |
| قاعدة البيانات: |
BASE |
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