Academic Journal
Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population ; ENEngelskEnglishCarotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population
| العنوان: | Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population ; ENEngelskEnglishCarotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population |
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| المؤلفون: | Ihle-Hansen, Håkon, Vigen, Thea, Berge, Trygve, Walle-Hansen, Marte, Hagberg, Guri, Ihle-Hansen, Hege Beathe, Thommessen, Bente, Ariansen, Inger, Røsjø, Helge Rørvik, Rønning, Ole Morten, Tveit, Arnljot, Lyngbakken, Magnus Nakrem |
| المصدر: | 2047-9980. |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Background We aimed to explore the predictive value of the carotid plaque score, compared with the Systematic Coronary Risk Evaluation 2 (SCORE2) risk prediction algorithm, on incident ischemic stroke and major adverse cardiovascular events and establish a prognostic cutoff of the carotid plaque score. Methods and Results In the prospective ACE 1950 (Akershus Cardiac Examination 1950 study), carotid plaque score was calculated with ultrasonography at inclusion in 2012 to 2015. The largest plaque diameter in each extracranial segment of the carotid artery on both sides was scored from 0 to 3 points. The sum of points in all segments provided the carotid plaque score. The cohort was followed up by linkage to national registries for incident ischemic stroke and major adverse cardiovascular events (nonfatal ischemic stroke, nonfatal myocardial infarction, and cardiovascular death) throughout 2020. Carotid plaque score was available in 3650 (98.5%) participants, with mean±SD age of 63.9±0.64 years at inclusion. Only 462 (12.7%) participants were free of plaque, and and 970 (26.6%) had a carotid plaque score of >3. Carotid plaque score predicted ischemic stroke (hazard ratio [HR], 1.25 [95% CI, 1.15–1.36]) and major adverse cardiovascular events (HR, 1.21 [95% CI, 1.14–1.27]) after adjustment for SCORE2 and provided strong incremental prognostic information to SCORE2. The best cutoff value of carotid plaque score for ischemic stroke was >3, with positive predictive value of 2.5% and negative predictive value of 99.3%. Conclusions The carotid plaque score is a strong predictor of ischemic stroke and major adverse cardiovascular events, and it provides incremental prognostic information to SCORE2 for risk prediction. A cutoff score of >3 seems to be suitable to discriminate high‐risk subjects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Ihle-Hansen, Håkon Vigen, Thea Berge, Trygve Walle-Hansen, Marte Hagberg, Guri Ihle-Hansen, Hege Beathe Thommessen, Bente Ariansen, Inger Røsjø, Helge Rørvik Rønning, Ole Morten Tveit, Arnljot Lyngbakken, Magnus Nakrem . Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. Journal of the American Heart Association (JAHA). 2023, 12(17); http://hdl.handle.net/10852/105716; 2175796; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of the American Heart Association (JAHA)&rft.volume=12&rft.spage=&rft.date=2023; Journal of the American Heart Association (JAHA); 12; 17; https://doi.org/10.1161/JAHA.123.030739 |
| DOI: | 10.1161/JAHA.123.030739 |
| الاتاحة: | http://hdl.handle.net/10852/105716 https://doi.org/10.1161/JAHA.123.030739 |
| Rights: | Attribution-NonCommercial 4.0 International ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.2FBE4F68 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/JAHA.123.030739 |
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