Academic Journal
Whole exome germline sequencing in early‐onset prostate cancer patients: Genomic findings and clinical outcomes
| العنوان: | Whole exome germline sequencing in early‐onset prostate cancer patients: Genomic findings and clinical outcomes |
|---|---|
| المؤلفون: | Siegelmann‐Danieli, Nava, Neiman, Victoria, Bareket‐Samish, Avital, Berger, Racheli, Peretz, Asaf, Alapi, Hillel, Tsur, Erez, Patalon, Tal, Beller, Daniella, Rimler, Galit, Chodick, Gabriel, Shohat, Mordechai |
| المصدر: | The Prostate ; volume 84, issue 1, page 39-46 ; ISSN 0270-4137 1097-0045 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Whole exome sequencing (WES) furthered our understanding of various tumors. We assessed the occurrence of germline likely pathogenic/pathogenic (LP/P) variants, disease features, and clinical outcomes in early‐onset prostate cancer. Methods This retrospective study ( N = 134) included consecutive prostate cancer patients who donated blood samples for research purposes to the Kahn‐Sagol‐Maccabi biobank. Patients diagnosed at >65 years were excluded. Clinical characteristics were extracted from the medical records. Germline WES was performed with analysis reporting on oncogenetic, two immunogenic, and a secondary minimum list panels (121, 468, 76, and 59 genes, respectively). Results Median age at diagnosis was 61 (range 46–65) years; 131 (98%) were diagnosed with local disease. The median follow‐up time from diagnosis was 14 (range <1–25) years. Of the patients with local disease, 32 (24%) and 10 (8%) had biochemical and distant recurrences, respectively. Twenty‐five patients (19%) had ≥1 additional cancer (excluding non‐melanoma skin cancer), most frequently bladder (6), colorectal (5), and lymphoma (5). Seven (5%) deaths were reported, with only one related to prostate cancer. LP/P variants were identified in 8 patients (6%), all in genes from the oncogenetic panel: ATM , BRCA1 (in two patients), BRCA2 (in two patients), HOXB13 , MUTYH , and MYH7 . Of these eight patients, with a median follow‐up of 7 years (range <1–15), two (25%) had biochemical recurrences, one had (12.5%) distant recurrence, and no deaths were reported. Conclusions In this cohort of 134 early‐onset prostate cancer patients, we identified germline LP/P variants in an oncogenetic panel in 6% of participants, with no unique clinical outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/pros.24622 |
| الاتاحة: | http://dx.doi.org/10.1002/pros.24622 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pros.24622 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.2FABB560 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/pros.24622 |
|---|