Academic Journal
Bioinspired BSA@polydopamine@Fe Nanoprobe with Self-Purification Capacity for Targeted Magnetic Resonance Imaging of Acute Kidney Injury
| العنوان: | Bioinspired BSA@polydopamine@Fe Nanoprobe with Self-Purification Capacity for Targeted Magnetic Resonance Imaging of Acute Kidney Injury |
|---|---|
| المؤلفون: | Quan Zou, Xi Chen, Bingjie Li, Ruijie Zhang, Jinbin Pan, Xuejun Zhang, Xuening Zhang, Shao-Kai Sun |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Marine Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, reabsorption effect toward, effortlessly detected via, powerful antioxidant capacity, aggravate renal damage, current contrast agents, acute kidney injury, prepared nanoprobe owns, renal cortex due, poor targeting capacity, mri contrast agent, bovine serum albumin, 1 , bpfe nanoprobe would, serum albumin, renal tubule, purification capacity, targeting ability, kidney diseases, based agents, >< sub |
| الوصف: | Contrast-enhanced magnetic resonance imaging (CE-MRI) of acute kidney injury (AKI) is severely hindered by the poor targeting capacity and potential toxicity of current contrast agents. Herein, we propose one-step fabrication of a bovine serum albumin@polydopamine@Fe (BSA@PDA@Fe, BPFe) nanoprobe with self-purification capacity for targeted CE-MRI of AKI. BSA endows the BPFe nanoprobe with renal tubule-targeting ability, and PDA is capable of completely inhibiting the intrinsic metal-induced reactive oxygen species (ROS), which are always involved in Fe/Mn-based agents. The as-prepared nanoprobe owns a tiny size of 2.7 nm, excellent solubility, good T 1 MRI ability, superior biocompatibility, and powerful antioxidant capacity. In vivo CE-MRI shows that the BPFe nanoprobe can accumulate in the renal cortex due to the reabsorption effect toward the serum albumin. In the AKI model, impaired renal reabsorption function can be effortlessly detected via the diminishment of renal cortical signal enhancement. More importantly, the administration of the BPFe nanoprobe would not aggravate renal damage of AKI due to the outstanding self-purification capacity. Besides, the BPFe nanoprobe is employed for CE-MR angiography to visualize fine vessel structures. This work provides an MRI contrast agent with good biosafety and targeting ability for CE-MRI of kidney diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Bioinspired_BSA_polydopamine_Fe_Nanoprobe_with_Self-Purification_Capacity_for_Targeted_Magnetic_Resonance_Imaging_of_Acute_Kidney_Injury/25130254 |
| DOI: | 10.1021/acsnano.3c09193.s001 |
| الاتاحة: | https://doi.org/10.1021/acsnano.3c09193.s001 https://figshare.com/articles/journal_contribution/Bioinspired_BSA_polydopamine_Fe_Nanoprobe_with_Self-Purification_Capacity_for_Targeted_Magnetic_Resonance_Imaging_of_Acute_Kidney_Injury/25130254 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.2F9FC307 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsnano.3c09193.s001 |
|---|