Academic Journal
Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy
| العنوان: | Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy |
|---|---|
| المؤلفون: | Santos, Renato O., Secolin, Rodrigo, Barbalho, Patrícia G., Silva-Alves, Mariana S., Alvim, Marina K. M., Yasuda, Clarissa L., Rogerio, Fábio, Velasco, Tonicarlo R., Sakamoto, Americo C., Teixeira, Antonio L., Cendes, Fernando, Maurer-Morelli, Claudia V., Lopes-Cendes, Iscia |
| المصدر: | Frontiers in Neurology ; volume 12 ; ISSN 1664-2295 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | We aimed to investigate the role of interleukin-1 beta (IL-1β) in the mechanisms underlying mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). We assessed a cohort of 194 patients with MTLE+HS and 199 healthy controls. Patients were divided into those with positive and negative antecedent febrile seizures (FS). We used a multidimensional approach, including (i) genetic association with single nucleotide polymorphisms (SNPs) in the IL1B gene; (ii) quantification of the IL1B transcript in the hippocampal tissue of patients with refractory seizures; and (iii) quantification of the IL-1β protein in the plasma. We found a genetic association signal for two SNPs, rs2708928 and rs3730364 * C in the IL1B gene, regardless of the presence of FS (adjusted p = 9.62e–11 and 5.14e–07, respectively). We found no difference between IL1B transcript levels when comparing sclerotic hippocampal tissue from patients with MTLE+HS, without FS, and hippocampi from autopsy controls ( p > 0.05). Nevertheless, we found increased IL-1β in the plasma of patients with MTLE+HS with FS compared with controls ( p = 0.0195). Our results support the hypothesis of a genetic association between MTLE+HS and the IL1B gene |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fneur.2021.690847 |
| DOI: | 10.3389/fneur.2021.690847/full |
| الاتاحة: | http://dx.doi.org/10.3389/fneur.2021.690847 https://www.frontiersin.org/articles/10.3389/fneur.2021.690847/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.2F7D5520 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fneur.2021.690847 |
|---|