Academic Journal
Phenanthrenes in Chinese Yam Peel Exhibit Anti-inflammatory Activity, as Shown by Strong in Vitro Cyclooxygenase Enzyme Inhibition
| العنوان: | Phenanthrenes in Chinese Yam Peel Exhibit Anti-inflammatory Activity, as Shown by Strong in Vitro Cyclooxygenase Enzyme Inhibition |
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| المؤلفون: | Li, Qian, Zhang, Chuan-Rui, Dissanayake, Amila A., Gao, Qun-yu, Nair, Muraleedharan G. |
| المصدر: | Natural Product Communications ; volume 11, issue 9 ; ISSN 1934-578X 1555-9475 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2016 |
| الوصف: | Chinese yam ( Dioscorea opposita), peeled or whole, is a popular food item that is considered to be healthy. Often, the yam is peeled before cooking. However, it is also consumed with peel. Therefore, in this study, the peel of this yam was extracted sequentially with n-hexane, ethyl acetate and methanol, and studied for its health-benefits, using in vitro bioassays. Bioactivity-guided purifications of extracts of the peel afforded phenanthrenes (1-4), as characterized by spectroscopic methods. Phenanthrene 1 is a novel analogue. The extracts and isolates were tested for anti-inflammatory activity using cyclooxygenase enzyme (COX-1 and -2) inhibitory assays. All phenanthrenes isolated from the yam peel showed higher inhibition of COX enzymes than the over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, ibuprofen and naproxen. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1934578x1601100933 |
| DOI: | 10.1177/1934578X1601100933 |
| الاتاحة: | https://doi.org/10.1177/1934578x1601100933 https://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100933 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.2F729259 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1934578x1601100933 |
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