Academic Journal
The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs
| العنوان: | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
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| المؤلفون: | Lin, Huan, Li, Xuanyi, Zhang, Huiying, Mu, Yi, Wang, Xi, Konduru, Naveena, Ji, Renlong, Liu, Wen, Fei, Zhao, Jiang, Wen, Qiao, Yuehua |
| المصدر: | Frontiers in Neurology ; volume 16 ; ISSN 1664-2295 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2025 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs. Objective This study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model. Methods We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE). Results Increased ABR thresholds in EH models were statistically significant ( p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz ( p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes ( p > 0.05). Conclusion WAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fneur.2025.1444928 |
| DOI: | 10.3389/fneur.2025.1444928/full |
| الاتاحة: | https://doi.org/10.3389/fneur.2025.1444928 https://www.frontiersin.org/articles/10.3389/fneur.2025.1444928/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.2F6D08BC |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fneur.2025.1444928 |
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