Academic Journal
Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes: The EURODIAB prospective complications study
| العنوان: | Association of serum MicroRNA-145-5p levels with microvascular complications of type 1 Diabetes: The EURODIAB prospective complications study |
|---|---|
| المؤلفون: | Barutta, Federica, Bellini, Stefania, Guarrera, Simonetta, Matullo, Giuseppe, Schalkwijk, Casper, Stehouwer, Coen D, Chaturvedi, Nish, Soedamah-Muthu, Sabita S, Durazzo, Marilena, Gruden, Gabriella |
| المصدر: | Diabetes Research and Clinical Practice , 190 , Article 109987. (2022) |
| بيانات النشر: | ELSEVIER IRELAND LTD |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Type 1 diabetes, microRNAs, Diabetic complications, Cardiovascular diseases, Hypertension, Albuminuria, Diabetic nephropathy, Diabetic kidney disease, TGF-beta 1, SMOOTH-MUSCLE-CELLS, CARDIOVASCULAR-DISEASE, CIRCULATING MICRORNAS, EXPRESSION, RETINOPATHY, MECHANISMS, BIOMARKERS, TARGETS, MARKERS, MIRNAS |
| الوصف: | Aims: To investigate whether serum miR-145-5p levels were associated with micro-macrovascular chronic complications in patients with type 1 diabetes (DM1). Methods: A nested case-control study from the EURODIAB Prospective Complications Study was performed. Cases (n = 289) had one or more complications of diabetes, whereas controls (n = 153) did not have any complication. We measured miR-145-5p levels by qPCR and investigated the association with diabetes complications. Results: Mean miR-145-5p levels were significantly lower in cases with microangiopathy [2.12 (0.86–4.94)] compared to controls [3.15 (1.21–7.36), P < 0.05] even after adjustment for age, gender, and diabetes duration. In logistic regression analysis, miR-145-5p levels in the lowest tertile were associated with an over three-fold increased odds ratio (OR) of albuminuria [3.22 (1.17–8.81)], independently of both demographic and diabetes-related factors. In addition, mir145-5p levels in the lowest tertile were independently and inversely associated with arterial hypertension [1.96 (1.08–3.56)] and hypertension was the mediator of the relationship between miR-145-5p and albuminuria. Conclusions: In this large cohort of DM1 patients, we found an inverse association between miR-145-5p and albuminuria that was mediated by systemic hypertension. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10153529/1/Chaturvedi_Association%20of%20serum%20MicroRNA-145-5p%20levels%20with%20microvascular%20complications%20of%20type%201%20Diabetes_VoR.pdf; https://discovery.ucl.ac.uk/id/eprint/10153529/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10153529/1/Chaturvedi_Association%20of%20serum%20MicroRNA-145-5p%20levels%20with%20microvascular%20complications%20of%20type%201%20Diabetes_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10153529/ |
| Rights: | open |
| رقم الانضمام: | edsbas.2F55C5D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |