Academic Journal
Factors important for fusogenic activity of peptides: molecular modeling study of analogs of fusion peptide of influenza virus hemagglutinin
| العنوان: | Factors important for fusogenic activity of peptides: molecular modeling study of analogs of fusion peptide of influenza virus hemagglutinin |
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| المؤلفون: | Efremov, Roman G., Nolde, Dmitry E., Volynsky, Pavel E., Chernyavsky, Andrei A., Dubovskii, Peter V., Arseniev, Alexander S. |
| المصدر: | FEBS Letters ; volume 462, issue 1-2, page 205-210 ; ISSN 0014-5793 1873-3468 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1999 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Nine analogs of fusion peptide of influenza virus hemagglutinin whose membrane perturbation activity has been thoroughly tested [Murata et al. (1992) Biochemistry 31, 1986–1992; Murata et al. (1993) Biophys. J. 64, 724–734] were characterized by molecular modeling techniques with the aim of delineating any specific structural and/or hydrophobic properties inherent in peptides with fusogenic activity. It was shown that, regardless of characteristics common to all analogs (peripheral disposition at the water‐lipid interface, amphiphilic nature, α‐helical structure, etc.), only fusion active peptides reveal a specific ‘tilted oblique‐oriented’ pattern of hydrophobicity on their surfaces and a certain depth of penetration to the non‐polar membrane core. The conclusion was reached that these factors are among the most important for the specific destabilization of a bilayer, which is followed by membrane fusion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/s0014-5793(99)01505-7 |
| DOI: | 10.1016/S0014-5793%2899%2901505-7 |
| الاتاحة: | http://dx.doi.org/10.1016/s0014-5793(99)01505-7 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2899%2901505-7 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(99)01505-7 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2899%2901505-7 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.2F54B970 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/s0014-5793(99)01505-7 |
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