Academic Journal
Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city
| العنوان: | Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city |
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| المؤلفون: | Hollander, W.J. (Wouter) den, Holster, I.L. (Ingrid), Van Gilst, B. (Bianca), Vuuren, A.J. (Hanneke) van, Jaddoe, V.W.V. (Vincent), Hofman, A. (Albert), Perez, G.I., Kuipers, E.J. (Ernst), Moll, H.A. (Henriëtte), Blaser, M.J. (Martin J.) |
| المصدر: | Gut (English Edition): an international journal of gastroenterology & hepatology vol. 64 no. 8, pp. 1200-1208 |
| سنة النشر: | 2015 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | Objective: Helicobacter pylori colonisation rates in childhood have declined in Western populations, but it is unknown whether this trend is similar in children of non-Western ethnic backgrounds, born in a Western country. We aimed to identify H. pylori status in children, and determine mother-to-child transmission and risk factors for colonisation. Design: Antibodies against H. pylori and cytotoxinassociated gene A (CagA) were measured in children participating in a population-based prospective cohort study in Rotterdam, the Netherlands. Information on demographics and characteristics was collected using questionnaires. Results: We analysed the serum of 4467 children (mean age 6.2 years±0.4 SD) and compared the results with the H. pylori status of their mothers (available for 3185 children). Overall, 438 (10%) children were H. pyloripositive, of whom 142 (32%) were CagA-positive. Independent risk factors for colonisation were: maternal H. pylori positivity (OR 2.12; 95% CI 1.62 to 2.77), non-Dutch ethnicity (OR 2.05; 95% CI 1.54 to 2.73), female gender (OR 1.47; 95% CI 1.20 to 1.80) and lower maternal education level (OR 1.38; 95% CI 1.06 to 1.79). Comparing mothers and children, we found an intergenerational decrease of 76% and 77% for Hp+ CagA- and Hp+ CagA+-strains, respectively, consistent across all nine ethnic groups studied. Male gender, higher maternal educational level and no older siblings, were independently associated with absence of H. pylori. Conclusions: Although the highest H. pylori and CagA prevalence was found in children of non-Dutch ethnicities, the decreased colonisation rates were uniform across all ethnic groups, implying the importance of environmental factors in H. pylori transmission in modern cities, independent of ethnicity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/84491; urn:hdl:1765/84491 |
| DOI: | 10.1136/gutjnl-2014-307689 |
| الاتاحة: | http://repub.eur.nl/pub/84491 https://doi.org/10.1136/gutjnl-2014-307689 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2F33B20E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/gutjnl-2014-307689 |
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