Academic Journal
Efficacy and safety of various oral regimens (three oral doses) and schedules (daily v. monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial
| العنوان: | Efficacy and safety of various oral regimens (three oral doses) and schedules (daily v. monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial |
|---|---|
| المؤلفون: | Ganie, Mohd Ashraf, Sidana, Shivani, Baba, Mohammad Salem, Sahar, Tajali, Rashid, Aafia, Asrar, Mir Mahmood, Marwaha, R K, Wani, Ishfaq Ahmad, Misgar, Riyaz A, Wani, Imtiyaz Ahmad |
| المصدر: | British Journal of Nutrition ; volume 129, issue 10, page 1732-1739 ; ISSN 0007-1145 1475-2662 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2022 |
| الوصف: | Vitamin D (VD) deficiency (serum 25 hydroxy vitamin D (25(OH)D) concentration of < 20 ng/ml), in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted among apparently healthy, VD-deficient subjects, aged 18–60 years who received 600 μg/d (Group A), 1000 μg/d (Group B), 2000 μg/d (Group C) and 60 000 μg/month (Group D) of oral cholecalciferol. The intervention was carried in two phases (I and II) of 12 weeks each, with same dose, separated by a washout phase of 12 weeks. Serum 25(OH)D, intact parathyroid hormones (iPTH), Ca, phosphorous (PO4), alkaline phosphatase (ALP) and spot urine Ca/Cr were measured at baseline, 12, 24 and 36 weeks following the intervention, and adverse events were recorded at each occurrence and at 12, 24 and 36 weeks. A statistically significant time–group interaction was found in serum 25(OH)D concentration ( P < 0·05). Serum 25(OH)D concentration increased significantly from baseline to 12 weeks ( P < 0·05) in all the groups with no change at 24 weeks but further increase at 36 weeks ( P < 0·05). At the end of the study, Group C had maximum increment in serum 25(OH)D concentration, while as Groups C and D (95 %, and 90 %) had higher proportion of subjects VD sufficient than Groups A and B (65 % and 78 %) ( P < 0·05). No significant time–dose interactions were observed in serum iPTH, Ca, PO4 and ALP or urine Ca/Cr ratio. Three subjects (two in Group C and one in Group D) developed transient hypercalciuria. Supplementation with daily 2000 μg or monthly 60 000 μg of oral cholecalciferol among adults seems optimal and safe. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s0007114522002641 |
| الاتاحة: | http://dx.doi.org/10.1017/s0007114522002641 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114522002641 |
| Rights: | https://www.cambridge.org/core/terms |
| رقم الانضمام: | edsbas.2F07B18C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s0007114522002641 |
|---|