Academic Journal
Comprehensive Virulence Gene Profiling of Bovine Non- aureus Staphylococci Based on Whole-Genome Sequencing Data
| العنوان: | Comprehensive Virulence Gene Profiling of Bovine Non- aureus Staphylococci Based on Whole-Genome Sequencing Data |
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| المؤلفون: | Naushad, Sohail, Naqvi, S. Ali, Nobrega, Diego, Luby, Christopher, Kastelic, John P., Barkema, Herman W., De Buck, Jeroen |
| المساهمون: | Kent, Angela D., NSERC Industrial Research Chair in Infectious Diseases of Dairy Cattle, Alberta Livestock and Meat Agency |
| المصدر: | mSystems ; volume 4, issue 2 ; ISSN 2379-5077 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2019 |
| الوصف: | Non- aureus staphylococci (NAS) are the most frequently isolated pathogens from milk in dairy cattle worldwide. The virulence factors (VFs) and mechanisms by which these bacteria cause udder infection are not fully known. We determined the distribution and associations of 191 VFs in 25 NAS species and investigated the relationship between VFs and disease. Although the overall number of VFs was not associated with disease severity, increasing numbers of toxin and host immune evasion genes specifically were associated with more severe disease outcomes. These findings suggest that the development of disease and the interactions of VFs with the host are complex and determined by the interplay of genes rather than just the presence of virulence genes. Together, our results provide foundational genetic knowledge to other researchers to design and conduct further experiments, focusing on understanding the synergy between VFs and roles of individual NAS species in IMI and characterizing species-specific effects on udder health. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/msystems.00098-18 |
| DOI: | 10.1128/mSystems.00098-18 |
| الاتاحة: | http://dx.doi.org/10.1128/msystems.00098-18 https://journals.asm.org/doi/pdf/10.1128/mSystems.00098-18 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.2ED2B3E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/msystems.00098-18 |
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