Academic Journal
Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome
| العنوان: | Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome |
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| المؤلفون: | Morand, Alexandrine, Laniepce, Alice, Cabé, Nicolas, Boudehent, Céline, Segobin, Shailendra, Pitel, Anne-Lise |
| المساهمون: | Fonctionnement et Dysfonctionnement Cognitifs : Les âges de la vie (DysCo), Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service d'Addictologie CHU Caen, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Neuropsychologie et imagerie de la mémoire humaine (NIMH), Normandie Université (NU)-Normandie Université (NU)-GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), FRM : ING20140129160 |
| المصدر: | ISSN: 2632-1297 ; Brain Communications ; https://hal.science/hal-04848627 ; Brain Communications, 2024, 6 (5), pp.fcae294. ⟨10.1093/braincomms/fcae294⟩ ; https://academic.oup.com/braincomms/article/6/5/fcae294/7762560?login=true. |
| بيانات النشر: | CCSD Oxford University Press on behalf of the Guarantors of Brain |
| سنة النشر: | 2024 |
| المجموعة: | Université Paris 8 Vincennes-Saint-Denis: HAL |
| مصطلحات موضوعية: | alcohol use disorder, Korsakoff's syndrome, resting-state functional imaging, fronto-cerebellar circuit, Papez circuit, [SCCO]Cognitive science, [SHS]Humanities and Social Sciences |
| الوصف: | International audience ; Alcohol use disorder is a chronic disease characterized by an inappropriate pattern of drinking, resulting in negative consequences for the individual's physical, mental and social health. Korsakoff's syndrome is a complication of alcohol use disorder and is characterized by severe memory and executive deficits. The fronto-cerebellar and Papez circuits are structurally affected in patients with alcohol use disorder with and without Korsakoff’s syndrome. The first objective of the present study was to measure the effect of chronic and excessive alcohol consumption on resting-state functional connectivity of these two functional brain networks. The second objective was to identify, for the first time, resting-state functional connectivity abnormalities specific to amnesic patients with Korsakoff’s syndrome. In the present study, a neuropsychological assessment and a resting-state functional magnetic resonance imaging examination were conducted in 31 healthy controls (43.6 ± 6.1 years) and 46 patients (46.6 ± 9.1 years) with alcohol use disorder including 14 patients with Korsakoff’s syndrome (55.5 ± 5.3 years) to examine the effect of chronic and heavy alcohol consumption on functional connectivity of the fronto-cerebellar and the Papez circuits at rest and the specificity of functional connectivity changes in Korsakoff’s syndrome compared to alcohol use disorder without Korsakoff’s syndrome. The resting-state functional connectivity analyses focused on the nodes of the fronto-cerebellar and Papez circuits and combined region of interest and graph theory approaches, and whether these alterations are associated with the neuropsychological profile. In patients pooled together compared to controls, lower global efficiency was observed in the fronto-cerebellar circuit. In addition, certain regions of the fronto-cerebellar and Papez circuits were functionally hyperconnected at rest, which positively correlated with executive functions. Patients with Korsakoff’s syndrome showed lower ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/braincomms/fcae294 |
| الاتاحة: | https://hal.science/hal-04848627 https://hal.science/hal-04848627v1/document https://hal.science/hal-04848627v1/file/fcae294%20%281%29.pdf https://doi.org/10.1093/braincomms/fcae294 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2E90C904 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/braincomms/fcae294 |
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