Academic Journal
Association between frailty status and complications in patients undergoing surgical excision of malignant esophageal neoplasms
| العنوان: | Association between frailty status and complications in patients undergoing surgical excision of malignant esophageal neoplasms |
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| المؤلفون: | Shahrestani, Shane, Sayed, Sammy, Nasrollahi, Tania, Nasrollahi, Tasha, Huang, Linda, McGillivray, Erin, Chour, William, Foong, Andrew, Dowlatshahi, Shadi |
| المصدر: | Annals of Gastroenterology, 36(5), 517-523, (2023-09) |
| بيانات النشر: | Hellenic Society of Gastroenterology |
| سنة النشر: | 2023 |
| المجموعة: | Caltech Authors (California Institute of Technology) |
| مصطلحات موضوعية: | Gastroenterology |
| الوصف: | Background Research within the last decade highlights the patients' frailty status as an important predictor of esophageal cancer outcomes, but the literature evaluating frailty's role in these patients remains limited. We evaluated the role of frailty in patients undergoing resection of malignant esophageal neoplasms. Methods We used the Nationwide Readmissions Database from 2016 and 2017 to identify patients who underwent excision of a malignant esophageal neoplasm. Patient frailty was queried using the Johns Hopkins Adjusted Clinical Groups frailty-defining diagnosis indicator. Propensity score matching identified 289 frail patients and 281 non-frail patients. Mann-Whitney U testing was performed and receiver operating characteristic (ROC) curves were created, following the creation of logistic regression models for predicting discharge disposition. The area under the curve (AUC) served as a proxy for model performance. Results Frail patients had significantly more nonroutine discharges, longer inpatient lengths of stay, higher costs, more acute infections, posthemorrhagic anemia and deep vein thrombosis, and greater mortality (P<0.05). No significant differences were found between the 2 cohorts with respect to readmission rates, pulmonary embolism or dysphagia. Predictive models for patient discharge disposition demonstrated that frailty status in combination with age resulted in better ROC curves (AUC: 0.652) compared to models using age alone (AUC: 0.601). Conclusions Frailty was found to be significantly correlated with higher rates of inpatient medical complications following esophagectomy. The inclusion of patient frailty status in predictive models for discharge disposition resulted in a better predictive capacity compared to those using age alone. ; © Hellenic Society of Gastroenterology. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.20524/aog.2023.0825; https://www.ncbi.nlm.nih.gov/pmc/PMC10433248 |
| DOI: | 10.20524/aog.2023.0825 |
| الاتاحة: | https://doi.org/10.20524/aog.2023.0825 https://www.ncbi.nlm.nih.gov/pmc/PMC10433248 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons Attribution Share Alike 4.0 International ; https://creativecommons.org/licenses/by-sa/4.0/legalcode |
| رقم الانضمام: | edsbas.2E2112A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.20524/aog.2023.0825 |
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