Academic Journal
malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication
| العنوان: | malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication |
|---|---|
| المؤلفون: | Wirth, DF, Winzeler, EA, Fenton, B, Adams, JH, Ariey, F, Barillas-Mury, CV, Baum, J, Bhatia, SN, Billker, O, Bopp, SE, Catteruccia, F, Cowman, AF, Chitnis, CE, Crabb, BS, Deitsch, KW, Del Portillo, HA, Djimde, AA, Dobano, C, Duffy, PE, Duraisingh, MT, Happi, C, James, AA, LaMonte, G, Lukens, AK, Llinas, M, Mali, P, Marti, M, Martinez-Barnetche, J, McGovern, V, Mota, MM, Mueller, I, Ndiaye, D, Neafsey, DE, Ntoumi, F, Prachumsri, J, Sharma, P, Shaw, WR, Sinnis, P, Tolia, NH, Volkman, SK, Wenger, EA, Williamson, K |
| المساهمون: | Wellcome Trust |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, IN-VITRO CULTURE, PLASMODIUM-FALCIPARUM MALARIA, MOSQUITO ANOPHELES-GAMBIAE, LIVER-STAGE DEVELOPMENT, HIGH-THROUGHPUT ASSAY, GENE DRIVE SYSTEM, RED-BLOOD-CELLS, ARTEMISININ RESISTANCE, EX-VIVO, GAMETOCYTE DEVELOPMENT, 11 Medical And Health Sciences |
| الوصف: | Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1549-1277 |
| Relation: | PLoS Medicine; http://hdl.handle.net/10044/1/55484; https://dx.doi.org/10.1371/journal.pmed.1002451; 100993/Z/13/Z |
| DOI: | 10.1371/journal.pmed.1002451 |
| الاتاحة: | http://hdl.handle.net/10044/1/55484 https://doi.org/10.1371/journal.pmed.1002451 |
| Rights: | © 2017 The malERA Consultative Panel on Basic Science and Enabling Technologies. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.2E13DFF9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15491277 |
|---|---|
| DOI: | 10.1371/journal.pmed.1002451 |