Academic Journal
Comparison of Oral Health and Salivary Biomarkers in Children with Juvenile Idiopathic Arthritis and Healthy Individuals
| العنوان: | Comparison of Oral Health and Salivary Biomarkers in Children with Juvenile Idiopathic Arthritis and Healthy Individuals |
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| المؤلفون: | Çalışkan, C, Durmuş, B, Yıldırım, HS, Demir, F, Sözeri, B |
| المصدر: | Nigerian Journal of Clinical Practice ; volume 26, issue 12, page 1808-1816 ; ISSN 1119-3077 2229-7731 |
| بيانات النشر: | Medknow |
| سنة النشر: | 2023 |
| الوصف: | Aim: This study examines the effects of juvenile idiopathic arthritis (JIA) on the oral health and detectability of inflammatory biomarkers IL-17, tumour necrosis factor-alpha (TNF-α) and total antioxidant status (TAS) in the saliva of children with JIA. Patients and Methods: This study included 117 participants (39 patients with JIA and 78 systemically healthy subjects aged 8–12 years). Demographic data, responses to an oral health-related questionnaire, saliva samples, periodontal parameters [plaque index (PI), gingival index (GI) and bleeding on probing (BOP)] and dental recordings [facial profile (FP) and dental occlusion relationship (DOR)] were obtained. Enzyme-linked immunosorbent assays were used to determine the levels of salivary IL-17, TNF-α and TAS. Results: The Caries Assessment Spectrum and Treatment (CAST) index, FP and DOR distributions did not change between groups ( P > 0.05). JIA patients had more temporomandibular joint (TMJ) discomfort than gingivitis patients and healthy subjects ( P < 0.05). JIA patients had greater salivary IL-17 levels than healthy subjects ( P < 0.05). The healthy group’s TAS was higher than that of the JIA and gingivitis groups ( P < 0.05). Saliva TNF-α levels were similar between groups ( P > 0.05). PI, GI, BOP and TNF-α were positively associated with salivary IL-17 ( P < 0.001). Conclusion: Elevated salivary IL-17 and TAS levels could be used as biological markers for discriminating the clinical health status of children with JIA and gingivitis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4103/njcp.njcp_169_23 |
| الاتاحة: | https://doi.org/10.4103/njcp.njcp_169_23 https://journals.lww.com/10.4103/njcp.njcp_169_23 |
| رقم الانضمام: | edsbas.2DD476AE |
| قاعدة البيانات: | BASE |
| DOI: | 10.4103/njcp.njcp_169_23 |
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