Academic Journal
Evolution of H5N1 avian influenza viruses in Asia
| العنوان: | Evolution of H5N1 avian influenza viruses in Asia |
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| المؤلفون: | World Health Organization Global Influenza Program Surveillance Network, /, Aubin, Jean-Thierry, Azebi, Saliha, Balish, Amanda, Banks, Jill, Bhat, Niranjan, Bright, Rick, A., Brown, Ian, Buchy, Philippe, Burguière, Ana-Maria, Chen, Hua-Lan, Cheng, Peter, Cox, Nancy J, Crosier, Alice, Curns, Aaron, Cuvelier, Frédérique, Deng, Guohua, Desheva, Julia, Desvaux, Stéphanie, Nguyen, Hong Diep, Donis, Ruben, Douglas, Alan, Dowell, Scott F, Nguyen, Tien Dung, Edwards, Lindsay, Fukuda, Keiji, Garten, Rebecca, Govorkova, Elena, Gregory, Victoria, Hampson, Alan, Nguyen, Thi Khanh Hong, Harper, Scott, Hay, Alan, Hoffmann, Erich, Imai, Masaki, Itamura, Shigeyuki, Jadhao, Samadhan, Jeannin, Patricia, Kang, Chun, Katz, Jackie, Kim, Jae-Hong, Klimov, Alexander, Kwon, Yong-Kuk, Lee, Chang Won, Li, Yanbing, Song Lien, Phuong, Lim, Wilina, Pu Lin, Yi, Manuguerra, Jean-Claude, Reynes, Jean-Marc, Rousseaux, Claudine, Tardy-Panit, Maryse, Tu, Phan Van, van Der Werf, Sylvie, Vong, Sirenda |
| المساهمون: | Institut Pasteur Paris (IP), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur d'Ho Chi Minh Ville, Research at St. Jude Hospital was supported in part by grant AI95357 from the National Institutes of Health. |
| المصدر: | ISSN: 1080-6040. |
| بيانات النشر: | HAL CCSD Centers for Disease Control and Prevention |
| سنة النشر: | 2005 |
| المجموعة: | Institut Pasteur: HAL |
| مصطلحات موضوعية: | MESH: Animals, MESH: Antiviral Agents, MESH: Influenza in Birds, MESH: Influenza, Human, MESH: Neuraminidase, MESH: Phenotype, MESH: Phylogeny, MESH: Poultry, MESH: Poultry Diseases, MESH: Asia, MESH: Chickens, MESH: Evolution, Molecular, MESH: Genetic Variation, MESH: Hemagglutinin Glycoproteins, Influenza Virus, MESH: Humans, MESH: Influenza A Virus, H5N1 Subtype, MESH: Influenza Vaccines, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused > or =52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/16318689; pasteur-01836582; https://pasteur.hal.science/pasteur-01836582; https://pasteur.hal.science/pasteur-01836582/document; https://pasteur.hal.science/pasteur-01836582/file/2005-EID%20H5N1%20Cambodia.pdf; PUBMED: 16318689; PUBMEDCENTRAL: PMC3366754 |
| DOI: | 10.3201/eid1110.050644 |
| الاتاحة: | https://pasteur.hal.science/pasteur-01836582 https://pasteur.hal.science/pasteur-01836582/document https://pasteur.hal.science/pasteur-01836582/file/2005-EID%20H5N1%20Cambodia.pdf https://doi.org/10.3201/eid1110.050644 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2DD2AC6F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3201/eid1110.050644 |
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