Academic Journal
Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series
| العنوان: | Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series |
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| المؤلفون: | Löwensteyn, Yvette N, Nair, Harish, Nunes, Marta C, van Roessel, Ichelle, Vernooij, Femke S, Willemsen, Joukje, Bont, Louis J, Mazur, Natalie I, Thorburn, Kentigern, Nunes, Marta, Chawana, Richard, Madhi, Shabir A, Vittuci, Anna C, Bassat, Quique, Bardají, Azucena, Goka, Edward, Roglić, Srđan, Paes, Bosco, Elliott, LouAnn, Oshitani, Hitoshi, Lupisan, Socorro, Gentile, Angela, Lucion, María Florencia, Spaeder, Michael C, Butt, Warwick, Thompson, Jenny, Mejias, Asuncion, Ramilo, Octavio, Fasce, Rodrigo A, Werner, Marta, Hijano, Diego R, Allison, Kim J, Pires, Márcia Rosane, de-Paris, Fernanda, Chakhunashvili, Giorgi, Karseladze, Irakli, Otieno, Grieven P, Nokes, D James, Scheuerman, Oded, Prais, Dario, Amad, Mohammed Al, Serouri, Abdul Wahed Al, Ali, Asad, Yousafzai, Mohammad Tahir, Bruno, Alfredo, de Mora, Domenica, Ojeda, Jenny, Dbaibo, Ghassan, Hanna-Wakim, Rima, Papaevangelou, Vassiliki, Kartisouni, Elpiniki, Cohen, Cheryl, Walaza, Sibongile, Linssen, Rosalie S, Chi, Hsin, Eşki, Aykut, Demir, Esen, Saha, Senjuti, Saha, Samir K, Sochet, Anthony A, Teppa-Sanchez, Beatriz E, Ravindranath, Thyyar M, Baird, J Scott, Morris, Shaun K, Wong, Waison, Breiman, Robert F, Gurley, Emily S, Arifeen, Shams El, Assefa, Nega, Scott, J Anthony G, Onyango, Dickens, Kotloff, Karen L, Sow, Samba O, Mandomando, Inacio, Ogbuanu, Ikechukwu U, Jambai, Amara, Kendirli, Tanil, Botan, Edin, Rubio, Franco Díaz, Serra, Alberto, Martinez, Luis, Pedroso, Luis, Menta, Soledad, Pardo, Rosalba, Donoso, Alejandro, Mahmood, Syed Faisal, Khan, Naveera |
| المصدر: | urn:ISSN:2589-5370 ; EClinicalMedicine, 37, 100945 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Influenza, Prevention, Pneumonia & Influenza, Emerging Infectious Diseases, Clinical Research, Infectious Diseases, Vaccine Related, Immunization, Pediatric, Infection, 3 Good Health and Well Being, FLU GOLD study group |
| الوصف: | BACKGROUND: Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking. METHODS: We invited clinicians and researchers to share clinical and demographic characteristics from children younger than 5 years who died with laboratory-confirmed influenza infection between January 1, 1995 and March 31, 2020. We evaluated the potential impact of maternal vaccination by estimating the number of children younger than 3 months with in-hospital influenza-related death using published global mortality estimates. FINDINGS: We included 314 children from 31 countries. Comorbidities were present in 166 (53%) children and 41 (13%) children were born prematurely. Median age at death was 8·6 (IQR 4·5-16·6), 11·5 (IQR 4·3-24·0), and 15·5 (IQR 7·4-27·0) months for children from low- and lower-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs), respectively. The proportion of children younger than 3 months at time of death was 17% in LMICs, 12% in UMICs, and 7% in HICs. We estimated that 3339 annual influenza-related in-hospital deaths occur in the first 3 months of life globally. INTERPRETATION: In our study, less than 20% of children is younger than 3 months at time of influenza-related death. Although maternal influenza vaccination may impact maternal and infant influenza disease burden, additional immunisation strategies are needed to prevent global influenza-related childhood mortality. The missing data, global coverage, and data quality in this study should be taken into consideration for further interpretation of the results. FUNDING: Bill & Melinda Gates Foundation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/1959.4/unsworks_78952; https://unsworks.unsw.edu.au/bitstreams/a683fe42-b371-4b91-80eb-a9de1db5fde1/download; https://doi.org/10.1016/j.eclinm.2021.100945 |
| DOI: | 10.1016/j.eclinm.2021.100945 |
| الاتاحة: | http://hdl.handle.net/1959.4/unsworks_78952 https://unsworks.unsw.edu.au/bitstreams/a683fe42-b371-4b91-80eb-a9de1db5fde1/download https://doi.org/10.1016/j.eclinm.2021.100945 |
| Rights: | open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| رقم الانضمام: | edsbas.2DB43505 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.eclinm.2021.100945 |
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