Academic Journal
CD97 is a critical regulator of acute myeloid leukemia stem cell function
| العنوان: | CD97 is a critical regulator of acute myeloid leukemia stem cell function |
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| المؤلفون: | Martin, Gaëlle H., Roy, Nainita, Chakraborty, Sohini, Desrichard, Alexis, Chung, Stephen S., Woolthuis, Carolien M., Hu, Wenhuo, Berezniuk, Iryna, Garrett-Bakelman, Francine E., Hamann, Jörg, Devlin, Sean M., Chan, Timothy A., Park, Christopher Y. |
| المساهمون: | Leukemia and Lymphoma Society, New York State Stem Cell Science, National Cancer Institute, American Society of Hematology |
| المصدر: | Journal of Experimental Medicine ; volume 216, issue 10, page 2362-2377 ; ISSN 0022-1007 1540-9538 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2019 |
| الوصف: | Despite significant efforts to improve therapies for acute myeloid leukemia (AML), clinical outcomes remain poor. Understanding the mechanisms that regulate the development and maintenance of leukemic stem cells (LSCs) is important to reveal new therapeutic opportunities. We have identified CD97, a member of the adhesion class of G protein–coupled receptors (GPCRs), as a frequently up-regulated antigen on AML blasts that is a critical regulator of blast function. High levels of CD97 correlate with poor prognosis, and silencing of CD97 reduces disease aggressiveness in vivo. These phenotypes are due to CD97’s ability to promote proliferation, survival, and the maintenance of the undifferentiated state in leukemic blasts. Collectively, our data credential CD97 as a promising therapeutic target on LSCs in AML. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20190598 |
| الاتاحة: | http://dx.doi.org/10.1084/jem.20190598 https://rupress.org/jem/article-pdf/216/10/2362/1765730/jem_20190598.pdf |
| Rights: | http://www.rupress.org/terms/ ; https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| رقم الانضمام: | edsbas.2DA3E6CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20190598 |
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