Academic Journal
DELINEATION OF CONFORMATIONAL AND STRUCTURAL FEATURES OF THE AMIKACIN-CU(II) COMPLEX IN WATER SOLUTION BY 13C-NMR SPECTROSCOPY
| العنوان: | DELINEATION OF CONFORMATIONAL AND STRUCTURAL FEATURES OF THE AMIKACIN-CU(II) COMPLEX IN WATER SOLUTION BY 13C-NMR SPECTROSCOPY |
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| المؤلفون: | E. GAGGELLI, N. GAGGELLI, A. MACCOTTA, G. VALENSIN, D. MARINI, DI COCCO, Maria Enrica, MANETTI, Cesare, DELFINI, Maurizio |
| المساهمون: | E., Gaggelli, N., Gaggelli, A., Maccotta, G., Valensin, D., Marini, DI COCCO, Maria Enrica, Manetti, Cesare, Delfini, Maurizio |
| بيانات النشر: | PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| سنة النشر: | 1999 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | amikacin, copper, C-13-NMR, nuclear relaxation rates |
| الوصف: | The copper (II) complex of amikacin in water solution at pH 5.5 was investigated by C-13-NMR. The temperature dependence of spin-lattice relaxation rates was measured and fast exchange conditions were shown to apply. The motional correlation time of the complex was approximated by the pseudo-isotropic rotational correlation time of free amikacin in water solution (tau(c) = 0.17 ns at 300 K). Formation of a pseudo-tetrahedral 1:1 complex was demonstrated by relaxation rates analysis and also by UV-Vis spectrophotometry. Two amino nitrogens of amikacin, together with the amide nitrogen and the hydroxyl in the hydroxyl-aminopropyl carbonyl side chain, were assigned as the copper-binding sites and a model of the complex was built by using copper-carbon distances obtained by NMR analysis as input parameters. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/10085575; info:eu-repo/semantics/altIdentifier/wos/WOS:000077930600021; volume:55; issue:1; firstpage:205; lastpage:210; numberofpages:6; journal:SPECTROCHIMICA ACTA. PART A, MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; http://hdl.handle.net/11573/245771; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0348198539; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000077930600021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a; http://www.sciencedirect.com/science/article/pii/S1386142598002315; http://www.scopus.com/inward/record.url?eid=2-s2.0-0032609446&partnerID=65&md5=a39095ca080203a0a0873353d32ef05a |
| DOI: | 10.1016/S1386-1425(98)00231-5 |
| الاتاحة: | http://hdl.handle.net/11573/245771 https://doi.org/10.1016/S1386-1425(98)00231-5 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000077930600021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.sciencedirect.com/science/article/pii/S1386142598002315 http://www.scopus.com/inward/record.url?eid=2-s2.0-0032609446&partnerID=65&md5=a39095ca080203a0a0873353d32ef05a |
| رقم الانضمام: | edsbas.2D956322 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1386-1425(98)00231-5 |
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