Academic Journal
MRI-serum-based score accurately identifies liver transplant patients without rejection avoiding need for liver biopsy: A multisite European study
| العنوان: | MRI-serum-based score accurately identifies liver transplant patients without rejection avoiding need for liver biopsy: A multisite European study |
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| المؤلفون: | Schaapman, Jelte, Shumbayawonda, Elizabeth, Castelo-Branco, Miguel, Caseiro Alves, Filipe, Costa, Tania, Fitzpatrick, Emer, Tupper, Katie, Dhawan, Anil, Deheragoda, Maesha, Sticova, Eva, French, Marika, Beyer, Cayden, Rymell, Soubera, Tonev, Dimitar, Verspaget, Hein, Neubauer, Stefan, Banerjee, Rajarshi, Lamb, Hildo, Coenraad, Minneke |
| المصدر: | Liver Transplantation ; ISSN 1527-6465 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| الوصف: | Background: Serum liver tests (serum tests) and histological assessment for T-cell mediated (TcM) rejection are essential for post-liver transplant monitoring. Liver biopsy carries risk of complications which are preferably avoided in low-risk patients. Multiparametric MRI (mpMRI) is a reliable non-invasive diagnostic method which quantifies liver disease activity and has prognostic utility. Our aim was to determine whether using mpMRI in combination with serum tests could noninvasively identify low-risk post-liver transplant patients who are eligible to avoid invasive liver biopsies. Methods: In a multicentre prospective study (RADIcAL2), including 131 adult and paediatric (children and adolescent) patients with previous liver transplant from the Netherlands, Portugal, and UK, concomitant mpMRI and liver biopsies were performed. Biopsies were centrally read by two expert pathologists. TcM rejection was assessed using BANFF global assessment (BANFF-GA). Diagnostic accuracy to discriminate no rejection vs. indeterminate or TcM liver transplant rejection was performed using area under the receiver operating characteristic curve (AUC). Results: In this study, 52% of patients received a routine (protocol) biopsy whilst 48% had a biopsy for suspicion of pathology. 38% of patients had no rejection, while 62% had either indeterminate (21%) or TcM rejection (41%). However, there was a high inter-observer variability (0 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/lvt.0000000000000450 |
| DOI: | 10.1097/LVT.0000000000000450 |
| الاتاحة: | http://dx.doi.org/10.1097/lvt.0000000000000450 https://journals.lww.com/10.1097/LVT.0000000000000450 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.2D84A8C3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/lvt.0000000000000450 |
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