التفاصيل البيبلوغرافية
| العنوان: |
Dysfunction, oxidative stress markers, and cytokine expression in the placentae of mice experimentally infected with Neospora caninum |
| المؤلفون: |
Mendoza Morales, Luisa Fernanda, Lagorio, Valentina, Corigliano, Mariana Georgina, Sánchez López, Edwin Fernando, Ramos Duarte, Víctor Andrés, Legarralde, César Ariel, Ganuza, Agustina, Clemente, Marina, Sander, Valeria Analia |
| بيانات النشر: |
Springer |
| المجموعة: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: |
ABORTION, CYTOKINES, NEOSPORA CANINUM, OXIDATIVE STRESS, PLACENTA, PROGESTERONE, https://purl.org/becyt/ford/4.3, https://purl.org/becyt/ford/4 |
| الوصف: |
Neosporosis is the major cause of abortion and reproductive failures in cattle, leading to significant economic losses. In this study, we evaluated the impact of Neospora caninum infection on oxidative stress (OS) markers and local cytokine mRNA expression at the placenta, as well as its effect on the progesterone (P4) serum levels and systemic cytokine profile in a pregnant mouse model. Infected pregnant mice (NC-1 group) showed increased percentages of fetal losses and IFN-γ serum levels, decreased serum progesterone, increased placental mRNA expression levels of both Th1-type (IFN-γ and TNF-α) and Th2-type (IL-4) cytokines, and inhibited expression of TGF-β1 (Treg) compare to control dams (CONTROL group). In addition, lipid peroxidation and ROS were increased, whereas the antioxidant enzymes, superoxide dismutase (SOD), and catalase (CAT) activities were modified in the placentae of infected mice compared to control mice. These findings demonstrate that multiple factors, including placental OS, are involved in fetal losses associated with N. caninum infection in mice, thus OS contribution to the placental physiopathology of neosporosis in other hosts must not be ruled out. ; Fil: Mendoza Morales, Luisa Fernanda. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Lagorio, Valentina. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Corigliano, Mariana Georgina. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Sánchez López, Edwin Fernando. Universidad ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0932-0113 |
| Relation: |
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s00436-023-07995-0; http://hdl.handle.net/11336/223567; Mendoza Morales, Luisa Fernanda; Lagorio, Valentina; Corigliano, Mariana Georgina; Sánchez López, Edwin Fernando; Ramos Duarte, Víctor Andrés; et al.; Dysfunction, oxidative stress markers, and cytokine expression in the placentae of mice experimentally infected with Neospora caninum; Springer; Parasitology Research; 122; 12; 10-2023; 3257-3263; CONICET Digital; CONICET |
| الاتاحة: |
http://hdl.handle.net/11336/223567 |
| Rights: |
info:eu-repo/semantics/restrictedAccess ; Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR) ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| رقم الانضمام: |
edsbas.2D80F27B |
| قاعدة البيانات: |
BASE |