Academic Journal
Periatrial epicardial fat is associated with markers of endothelial dysfunction in patients with atrial fibrillation
| العنوان: | Periatrial epicardial fat is associated with markers of endothelial dysfunction in patients with atrial fibrillation |
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| المؤلفون: | Girerd, N., Scridon, A., Bessiere, F., Chauveau, S., Geloen, A., Boussel, L., Morel, E., Chevalier, P. |
| المساهمون: | Centre d'investigation clinique plurithématique Pierre Drouin Nancy (CIC-P), Centre d'investigation clinique Nancy (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Physiology Department, University of Medicine and Pharmacy of Tîrgu Mureș, Unité de neurocardiologie : physiopathologie des troubles du rythme cardiaque, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fédération Nationale des Agriculteurs Multiplicateurs de Semences (FNAMS), STMicroelectronics Crolles (ST-CROLLES) |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2013 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | WILLEBRAND-FACTOR LEVELS, CELL-ADHESION MOLECULES, ADIPOSE-TISSUE, PERICARDIAL FAT, CATHETER ABLATION, RISK-FACTOR, FOLLOW-UP, OBESITY, PREDICTORS, EXPRESSION, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging |
| الوصف: | [PubMed Central:\hrefhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797107PMC3797107] [DOI:\hrefhttps://dx.doi.org/10.1371/journal.pone.007716710.1371/journal.pone.0077167] [PubMed:\hrefhttps://www.ncbi.nlm.nih.gov/pubmed/2137164421371644] ; International audience ; Epicardial adipose tissue (EAT) is associated to atrial fibrillation (AF) burden and outcome after AF ablation. We intended to determine whether global or local EAT is associated with systemic and/or left atrial (LA) inflammation and markers of endothelial dysfunction in AF patients.\ Total, atrial, and ventricular EAT volume (EAT total, EAT atrial, EAT ventricular) were measured by multislice cardiac CT in 49 patients with paroxysmal (PAF, n=25) or persistent AF (PeF, n=24). Periatrial epicardial fat thickness at the esophagus (LA-ESO) and thoracic aorta (LA-ThA) were also measured. Vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), soluble intercellular adhesion molecule 1 (sICAM-1), transforming growth factor-β1 (TGF-β1), and von Willebrand Factor (vWF) levels were measured in peripheral and LA blood samples obtained during catheterization during AF ablation. Patients with PeF had higher EAT atrial (P<0.05) and LA-ESO (P=0.04) than patients with PAF. VEGF, IL-8, and TGF-β1 were not associated with EAT. In contrast, after adjusting for LA volume and body mass index, higher LA-ThA was significantly associated with higher sICAM-1 and vWF levels, both in peripheral blood (P<0.05) and in LA (P<0.05). Similar results were found with LA-ESO. Body mass index, EAT total and EAT ventricular were not associated with sICAM-1 and vWF.\ Periatrial epicardial fat showed a significant positive association with increased levels of sICAM-1 and vWF, which are biomarkers of endothelial dysfunction. No such associations were found when considering body mass index or EAT total. These results suggest that local EAT rather than regional or total adiposity may modulate endothelial dysfunction in patients with AF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24143210; hal-02076774; https://hal.science/hal-02076774; https://hal.science/hal-02076774/document; https://hal.science/hal-02076774/file/2013_Girerd_Plos%20One_1.pdf; PRODINRA: 221852; PUBMED: 24143210; PUBMEDCENTRAL: PMC3797107; WOS: 000325894100045 |
| DOI: | 10.1371/journal.pone.0077167 |
| الاتاحة: | https://hal.science/hal-02076774 https://hal.science/hal-02076774/document https://hal.science/hal-02076774/file/2013_Girerd_Plos%20One_1.pdf https://doi.org/10.1371/journal.pone.0077167 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2D7F4D1B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0077167 |
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