Academic Journal
Psychoneuroendocrinology / High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: a preliminary report
| العنوان: | Psychoneuroendocrinology / High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: a preliminary report |
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| المؤلفون: | Lanzenberger, Rupert, Spies, Marie, Kranz, Georg S., Vraka, Chrysoula, Kaufmann, Ulrike, Klebermass, Eva-Maria, Handschuh, Patricia A., Ozenil, Marius, Murgaš, Matej, Pichler, Verena, Rischka, Lucas, Nics, Lukas, Konadu, Melisande E., Ibeschitz, Harald, Traub-Weidinger, Tatjana, Wadsak, Wolfgang, Hahn, Andreas, Hacker, Marcus |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| مصطلحات موضوعية: | Monoamine oxidase A, Testosterone, Estradiol, Gender-affirming hormone treatment, Gender dysphoria, Transgender, Positron emission tomography |
| جغرافية الموضوع: | UMW:14636, UMW:14620, UMW:14633 |
| الوصف: | The sex hormones testosterone and estradiol influence brain structure and function and are implicated in the pathogenesis, prevalence and disease course of major depression. Recent research employing gender-affirming hormone treatment (GHT) of gender dysphoric individuals and utilizing positron emission tomography (PET) indicates increased serotonin transporter binding upon high-dosages of testosterone treatment. Here, we investigated the effects of GHT on levels of monoamine oxidase A (MAO-A), another key target of antidepressant treatment. Participants underwent PET with the radioligand [11C]harmine to assess cerebral MAO-A distribution volumes (VT) before and four months after initiation of GHT. By the time this study was terminated for technical reasons, 18 transgender individuals undergoing GHT (11 transmen, TM and 7 transwomen, TW) and 17 cis-gender subjects had been assessed. Preliminary analysis of available data revealed statistically significant MAO-A VT reductions in TM under testosterone treatment in six of twelve a priori defined regions of interest (middle frontal cortex (−10%), anterior cingulate cortex (−9%), medial cingulate cortex (−10.5%), insula (−8%), amygdala (−9%) and hippocampus (−8.5%, all p<0.05)). MAO-A VT did not change in TW receiving estrogen treatment. Despite the limited sample size, pronounced MAO-A VT reduction could be observed, pointing towards a potential effect of testosterone. Considering MAO-A’s central role in regulation of serotonergic neurotransmission, changes to MAO-A VT should be further investigated as a possible mechanism by which testosterone mediates risk for, symptomatology of, and treatment response in affective disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-50747/128; urn:nbn:at:at-ubmuw:3-50747; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-50747; local:99146361249403331; system:AC16356153 |
| DOI: | 10.1016/j.psyneuen.2021.105381 |
| الاتاحة: | https://doi.org/10.1016/j.psyneuen.2021.105381 https://repositorium.meduniwien.ac.at/doi/10.1016/j.psyneuen.2021.105381 https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-50747 |
| Rights: | cc-by_4 |
| رقم الانضمام: | edsbas.2D74BF3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.psyneuen.2021.105381 |
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