التفاصيل البيبلوغرافية
| العنوان: |
Brief Definitive Report Fibroblasts Mediate T Cell Survival: A Proposed Mechanism for Retention of Primed T Cells |
| المؤلفون: |
Sumi Scott, Franco P, James T. Kurnick |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8d/54/J_Exp_Med_1990_Dec_1_172(6)_1873-1876.tar.gz |
| المجموعة: |
CiteSeerX |
| الوصف: |
This report describes a salvage pathway whereby activated T lymphocytes revert to nonproliferating cells in the absence of antigen or mitogenic signals. After the removal of mitogenic cytokines, cultured T lymphocytes cease dividing and rapidly begin to undergo cell death. However, the addition of fibroblasts to interleukin 2 (IL2)-propagated T cells results in prolonged survival of the previously activated T lymphocytes in the absence of proliferation. The prevention of cell death is also achieved by conditioned medium from the fibroblasts. T lymphocytes cultured with fibroblasts or the conditioned medium retain the ability to be restimulated if mitogenic stimuli are added to the culture. The activity is not accounted for by ILl-7. The studies suggest a stromal cell-mediated, nonspecific mechanism for survival of primed T lymphocytes in a nonproliferating state. Lmphocyte responses to antigens can be divided into three main phases: (a) antigen-driven activation; (b) clonal expansion and differentiation of effector cells; and (c) after removal of antigen, the retention of "primed " cells, which allows an accelerated response upon antigenic rechallenge. Although many details on the first two phases are understood; little is known about how primed cells are preserved. In fact, when activated cells are removed from the presence of antigenic stimuli or proliferation-inducing cytokines, they rapidly cease dividing and begin to deteriorate (1). We have observed that the presence of the tissue enhanced the survival and activation of T lymphocytes (2). Stimulatory antigens could account for this enhanced activation (3), but we have now shown that fibroblasts alone, or even supernatants derived from fibroblast cultures, are also able to support the survival of T lymphocytes. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.4034 |
| الاتاحة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.4034 |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.2D6130C2 |
| قاعدة البيانات: |
BASE |