Academic Journal
The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition
| العنوان: | The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition |
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| المؤلفون: | Parnaudeau, Sebastien, Bolkan, Scott, Kellendonk, Christoph |
| المساهمون: | Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-14-CE35-0029,PsyCoStress,Glucocorticoids and Psychiatric Disorders: Mechanisms of Stress Induced Cognitive Deficits(2014) |
| المصدر: | ISSN: 0006-3223 ; Biological Psychiatry ; https://hal.science/hal-03003626 ; Biological Psychiatry, 2018, 83 (8), pp.648-656. ⟨10.1016/j.biopsych.2017.11.008⟩. |
| بيانات النشر: | CCSD Elsevier |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Deficits in cognition are a core feature of many psychiatric conditions, including schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome. Impairment in cognitive domains such as working memory and behavioral flexibility has typically been associated with prefrontal cortex (PFC) dysfunction. However, there is increasing evidence that the PFC cannot be dissociated from its main thalamic counterpart, the mediodorsal thalamus (MD). Since the causal relationships between MD-PFC abnormalities and cognitive impairment, as well as the neuronal mechanisms underlying them, are difficult to address in humans, animal models have been employed for mechanistic insight. In this review, we discuss anatomical, behavioral, and electrophysiological findings from animal studies that provide a new understanding on how MD-PFC circuits support higher-order cognitive function. We argue that the MD may be required for amplifying and sustaining cortical representations under different behavioral conditions. These findings advance a new framework for the broader involvement of distributed thalamo-frontal circuits in cognition and point to the MD as a potential therapeutic target for improving cognitive deficits in schizophrenia and other disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.biopsych.2017.11.008 |
| الاتاحة: | https://hal.science/hal-03003626 https://hal.science/hal-03003626v1/document https://hal.science/hal-03003626v1/file/BPS13382.pdf https://doi.org/10.1016/j.biopsych.2017.11.008 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2D4E595D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.biopsych.2017.11.008 |
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